The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment
CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, including certain immune cells and cancer ones. This...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1783 |
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| author | Adrian Vasile Dumitru Dana Antonia Țăpoi Georgian Halcu Octavian Munteanu David-Ioan Dumitrascu Mihail Constantin Ceaușu Ancuța-Augustina Gheorghișan-Gălățeanu |
| author_facet | Adrian Vasile Dumitru Dana Antonia Țăpoi Georgian Halcu Octavian Munteanu David-Ioan Dumitrascu Mihail Constantin Ceaușu Ancuța-Augustina Gheorghișan-Gălățeanu |
| author_sort | Adrian Vasile Dumitru |
| collection | DOAJ |
| description | CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, including certain immune cells and cancer ones. This review aims to shed light on the critical importance of CD30, from its emergence in the cell to its position in diagnosing various diseases, including Hodgkin lymphoma, where it is expressed on Hodgkin and Reed–Sternberg cells, as well as embryonal carcinoma, anaplastic large cell lymphoma (ALCL), and cutaneous T-cell lymphoma (CTCL). In addition to its role in positive diagnosis, targeting CD30 has been a promising approach treating CD30-positive lymphomas, and there is ongoing research into the potential use of CD30-targeted therapies for autoimmune disorders. We aim to elaborate on CD30’s roles as a tumor marker, supporting thus the hypothesis that this receptor might be the aim of cytostatic treatment. |
| first_indexed | 2024-03-11T01:44:45Z |
| format | Article |
| id | doaj.art-04195325a7624de596342f9789fd21c6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:44:45Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-04195325a7624de596342f9789fd21c62023-11-18T16:20:00ZengMDPI AGCells2073-44092023-07-011213178310.3390/cells12131783The Polyvalent Role of CD30 for Cancer Diagnosis and TreatmentAdrian Vasile Dumitru0Dana Antonia Țăpoi1Georgian Halcu2Octavian Munteanu3David-Ioan Dumitrascu4Mihail Constantin Ceaușu5Ancuța-Augustina Gheorghișan-Gălățeanu6Department of Pathology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Anatomy, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaCD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, including certain immune cells and cancer ones. This review aims to shed light on the critical importance of CD30, from its emergence in the cell to its position in diagnosing various diseases, including Hodgkin lymphoma, where it is expressed on Hodgkin and Reed–Sternberg cells, as well as embryonal carcinoma, anaplastic large cell lymphoma (ALCL), and cutaneous T-cell lymphoma (CTCL). In addition to its role in positive diagnosis, targeting CD30 has been a promising approach treating CD30-positive lymphomas, and there is ongoing research into the potential use of CD30-targeted therapies for autoimmune disorders. We aim to elaborate on CD30’s roles as a tumor marker, supporting thus the hypothesis that this receptor might be the aim of cytostatic treatment.https://www.mdpi.com/2073-4409/12/13/1783CD30anaplastic large cell lymphomaembryonal carcinomaHodgkin lymphomacancer treatmenttumor marker |
| spellingShingle | Adrian Vasile Dumitru Dana Antonia Țăpoi Georgian Halcu Octavian Munteanu David-Ioan Dumitrascu Mihail Constantin Ceaușu Ancuța-Augustina Gheorghișan-Gălățeanu The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment Cells CD30 anaplastic large cell lymphoma embryonal carcinoma Hodgkin lymphoma cancer treatment tumor marker |
| title | The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment |
| title_full | The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment |
| title_fullStr | The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment |
| title_full_unstemmed | The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment |
| title_short | The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment |
| title_sort | polyvalent role of cd30 for cancer diagnosis and treatment |
| topic | CD30 anaplastic large cell lymphoma embryonal carcinoma Hodgkin lymphoma cancer treatment tumor marker |
| url | https://www.mdpi.com/2073-4409/12/13/1783 |
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