Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol
<strong>Objective:</strong> Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for<em> Zataria multiflora</em> (Z<em>. multiflora</em>) and carvacrol previously. The effects of Z<e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-09-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_14960_59e6a6744b6d3b9fc0a5be551a5e4c63.pdf |
| _version_ | 1818588756721008640 |
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| author | Fatemeh Amin Ali Roohbakhsh Arghavan Memarzia Hamid Kazerani Mohammad Hossein Boskabady |
| author_facet | Fatemeh Amin Ali Roohbakhsh Arghavan Memarzia Hamid Kazerani Mohammad Hossein Boskabady |
| author_sort | Fatemeh Amin |
| collection | DOAJ |
| description | <strong>Objective:</strong> Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for<em> Zataria multiflora</em> (Z<em>. multiflora</em>) and carvacrol previously. The effects of Z<em>. multiflora</em> hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stressinduced by inhaled PQ were examined in this study.<br /> <strong>Materials and Methods:</strong> Six groups of male rats used in this study were as follows: control group exposed to normal saline aerosol, one group exposed to PQ 54 mg/m<sup>3</sup> aerosol, animals exposed to PQ 54 mg/m<sup>3</sup> and treated with Z<em>. multiflora</em> (200 and 800 mg/kg/day) or carvacrol (20 and 80 mg/kg/day) for 16 days after the end of exposure to PQ. Exposure to PQ was performed 8 times, every other day, each time for 30 min. After the end of the treatment period, different variables were measured.<br /> <strong>Results:</strong> Significant increases in nitrite (NO<sub>2)</sub>, malondialdehyde (MDA) and interleukin (IL)-6 serum levels but significant reduction of interferon-gamma (IFN-γ) serum levels as well as IFN-γ/IL-6 ratio were observed in PQ-exposed compared to control group (p2, and IL-6 but increased IFN-γ and IFN-γ/IL-6 ratio compared to un-treated PQ exposed group (p <strong>Conclusion:</strong> Treatment with <em>Z. multiflora</em> and carvacrol improved systemic inflammation oxidative biomarkers induced by inhaled PQ which may indicate therapeutic potential of the plant and its constituent, carvacrol in systemic inflammation and oxidative biomarkers induced by inhaled PQ. |
| first_indexed | 2024-12-16T09:29:49Z |
| format | Article |
| id | doaj.art-0419c63ca3a0426391bcb9d753dc793b |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-16T09:29:49Z |
| publishDate | 2020-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-0419c63ca3a0426391bcb9d753dc793b2022-12-21T22:36:33ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492020-09-0110551352210.22038/ajp.2020.1496014960Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrolFatemeh Amin0Ali Roohbakhsh1Arghavan Memarzia2Hamid Kazerani3Mohammad Hossein Boskabady4Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.Pharmacutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, IranNeurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran<strong>Objective:</strong> Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for<em> Zataria multiflora</em> (Z<em>. multiflora</em>) and carvacrol previously. The effects of Z<em>. multiflora</em> hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stressinduced by inhaled PQ were examined in this study.<br /> <strong>Materials and Methods:</strong> Six groups of male rats used in this study were as follows: control group exposed to normal saline aerosol, one group exposed to PQ 54 mg/m<sup>3</sup> aerosol, animals exposed to PQ 54 mg/m<sup>3</sup> and treated with Z<em>. multiflora</em> (200 and 800 mg/kg/day) or carvacrol (20 and 80 mg/kg/day) for 16 days after the end of exposure to PQ. Exposure to PQ was performed 8 times, every other day, each time for 30 min. After the end of the treatment period, different variables were measured.<br /> <strong>Results:</strong> Significant increases in nitrite (NO<sub>2)</sub>, malondialdehyde (MDA) and interleukin (IL)-6 serum levels but significant reduction of interferon-gamma (IFN-γ) serum levels as well as IFN-γ/IL-6 ratio were observed in PQ-exposed compared to control group (p2, and IL-6 but increased IFN-γ and IFN-γ/IL-6 ratio compared to un-treated PQ exposed group (p <strong>Conclusion:</strong> Treatment with <em>Z. multiflora</em> and carvacrol improved systemic inflammation oxidative biomarkers induced by inhaled PQ which may indicate therapeutic potential of the plant and its constituent, carvacrol in systemic inflammation and oxidative biomarkers induced by inhaled PQ.http://ajp.mums.ac.ir/article_14960_59e6a6744b6d3b9fc0a5be551a5e4c63.pdfparaquatzataria multifloracarvacrol, oxidative biomarkers, inflammation |
| spellingShingle | Fatemeh Amin Ali Roohbakhsh Arghavan Memarzia Hamid Kazerani Mohammad Hossein Boskabady Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol Avicenna Journal of Phytomedicine paraquat zataria multiflora carvacrol, oxidative biomarkers, inflammation |
| title | Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol |
| title_full | Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol |
| title_fullStr | Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol |
| title_full_unstemmed | Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol |
| title_short | Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol |
| title_sort | paraquat induced systemic inflammation and increased oxidative markers in rats improved by zataria multiflora extract and carvacrol |
| topic | paraquat zataria multiflora carvacrol, oxidative biomarkers, inflammation |
| url | http://ajp.mums.ac.ir/article_14960_59e6a6744b6d3b9fc0a5be551a5e4c63.pdf |
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