Oscillation of Autophagy Induction under Cellular Stress and What Lies behind It, a Systems Biology Study

Oscillation of Autophagy Induction under Cellular Stress and What Lies behind It, a Systems Biology Study

One of the main inducers of autophagy-dependent self-cannibalism, called ULK1, is tightly regulated by the two sensor molecules of nutrient conditions and energy status, known as mTOR and AMPK kinases, respectively. Recently, we developed a freely available mathematical model to explore the oscillat...

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Bibliographic Details
Main Authors: Bence Hajdú, Luca Csabai, Margita Márton, Marianna Holczer, Tamás Korcsmáros, Orsolya Kapuy
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
feedback loops
autophagy
bistable switch
oscillation
mathematical modelling
Online Access:https://www.mdpi.com/1422-0067/24/8/7671

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