Identification of Somatic Genetic Alterations Using Whole-Exome Sequencing of Uterine Leiomyosarcoma Tumors

Identification of Somatic Genetic Alterations Using Whole-Exome Sequencing of Uterine Leiomyosarcoma Tumors

BackgroundThe genomic abnormalities associated with uterine leiomyosarcoma (uLMS) have not been fully elucidated to date.ObjectiveTo understand the pathogenesis of uLMS and to identify driver mutations and potential therapeutic targets in uLMS.MethodsThree matched tumor-constitutional DNA pairs from...

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Bibliographic Details
Main Authors: Lihua Chen, Jiajia Li, Xiaohua Wu, Zhong Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
exome sequencing
uterine leiomyosarcoma
SHARPIN
TP53
ULMS
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.687899/full

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