Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells

Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells

This study aimed at understanding the effect of metformin on histone H3 methylation, DNA methylation, and chromatin accessibility in lung cancer cells. Metformin significantly reduced H3K4me3 level at the promoters of positive cell cycle regulatory genes such as CCNB2, CDK1, CDK6, and E2F8. Eighty-e...

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Bibliographic Details
Main Authors: Dongho Kim, Yujin Kim, Bo Bin Lee, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
lung cancer
metformin
H3K4 methylation
MLL2
cell cycle
Online Access:https://www.mdpi.com/2072-6694/13/4/739

Internet

https://www.mdpi.com/2072-6694/13/4/739

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