Ramipril induced pemphigoid vulgaris
Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
KIMS Foundation and Research Center
2018-09-01
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| Series: | Journal of Medical and Scientific Research |
| Subjects: | |
| Online Access: | http://jmsronline.com/article.aspx?ID=Ramipril-induced-pemphigoid-vulgaris |
| Summary: | Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilation of arteries and veins. These actions bring about reduction in preload and afterload on heart. Side effects of ACE inhibitors include cough, dysgeusia, hyperkalaemia, renal failure, proteinuria, agranulocytosis etc. Seldomly ACE inhibitors precipitate skin rashes, pruritus & urticaria.
Case report: A 52-year-old female with known case of rheumatoid arthritis was prescribed ramipril for treatment of cardiomegaly and left ventricular (LV) dysfunction. The patient reported skin related adverse drug reaction i.e., pemphigoid vulgaris.
Conclusion: From the current case report it can be said that ramipril can cause and aggregate some rare skin adverse effects as that of pemphigoid vulgaris which can be reversed within a short span of time if recognized early. |
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| ISSN: | 2321-1326 2394-112X |