Ramipril induced pemphigoid vulgaris
Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilatio...
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| Format: | Article |
| Language: | English |
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KIMS Foundation and Research Center
2018-09-01
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| Series: | Journal of Medical and Scientific Research |
| Subjects: | |
| Online Access: | http://jmsronline.com/article.aspx?ID=Ramipril-induced-pemphigoid-vulgaris |
| _version_ | 1818482654207541248 |
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| author | Mirza MA Jena S |
| author_facet | Mirza MA Jena S |
| author_sort | Mirza MA |
| collection | DOAJ |
| description | Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilation of arteries and veins. These actions bring about reduction in preload and afterload on heart. Side effects of ACE inhibitors include cough, dysgeusia, hyperkalaemia, renal failure, proteinuria, agranulocytosis etc. Seldomly ACE inhibitors precipitate skin rashes, pruritus & urticaria.
Case report: A 52-year-old female with known case of rheumatoid arthritis was prescribed ramipril for treatment of cardiomegaly and left ventricular (LV) dysfunction. The patient reported skin related adverse drug reaction i.e., pemphigoid vulgaris.
Conclusion: From the current case report it can be said that ramipril can cause and aggregate some rare skin adverse effects as that of pemphigoid vulgaris which can be reversed within a short span of time if recognized early. |
| first_indexed | 2024-12-10T11:50:23Z |
| format | Article |
| id | doaj.art-0421db9b9ce24b01951d14f366db4913 |
| institution | Directory Open Access Journal |
| issn | 2321-1326 2394-112X |
| language | English |
| last_indexed | 2024-12-10T11:50:23Z |
| publishDate | 2018-09-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj.art-0421db9b9ce24b01951d14f366db49132022-12-22T01:49:57ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2018-09-016412212410.17727/JMSR.2018/6-20Ramipril induced pemphigoid vulgarisMirza MA0Jena S1Department of Cardiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, IndiaDepartment of Cardiology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, IndiaIntroduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to angiotensin II and also inhibits bradykinin metabolism thereby causing dilation of arteries and veins. These actions bring about reduction in preload and afterload on heart. Side effects of ACE inhibitors include cough, dysgeusia, hyperkalaemia, renal failure, proteinuria, agranulocytosis etc. Seldomly ACE inhibitors precipitate skin rashes, pruritus & urticaria. Case report: A 52-year-old female with known case of rheumatoid arthritis was prescribed ramipril for treatment of cardiomegaly and left ventricular (LV) dysfunction. The patient reported skin related adverse drug reaction i.e., pemphigoid vulgaris. Conclusion: From the current case report it can be said that ramipril can cause and aggregate some rare skin adverse effects as that of pemphigoid vulgaris which can be reversed within a short span of time if recognized early.http://jmsronline.com/article.aspx?ID=Ramipril-induced-pemphigoid-vulgarisramiprilangiotensin-converting enzymepemphigoid vulgaris |
| spellingShingle | Mirza MA Jena S Ramipril induced pemphigoid vulgaris Journal of Medical and Scientific Research ramipril angiotensin-converting enzyme pemphigoid vulgaris |
| title | Ramipril induced pemphigoid vulgaris |
| title_full | Ramipril induced pemphigoid vulgaris |
| title_fullStr | Ramipril induced pemphigoid vulgaris |
| title_full_unstemmed | Ramipril induced pemphigoid vulgaris |
| title_short | Ramipril induced pemphigoid vulgaris |
| title_sort | ramipril induced pemphigoid vulgaris |
| topic | ramipril angiotensin-converting enzyme pemphigoid vulgaris |
| url | http://jmsronline.com/article.aspx?ID=Ramipril-induced-pemphigoid-vulgaris |
| work_keys_str_mv | AT mirzama ramiprilinducedpemphigoidvulgaris AT jenas ramiprilinducedpemphigoidvulgaris |