A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis
Objective: To identify the febrile characteristics and clinical presentations associated with fatality in hospitalized adult patients with dengue virus (DENV) infections. Methods: A total of 289 adult hospitalized patients with laboratory-confirmed DENV infections were examined, of which 22 were fat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=7;spage=301;epage=307;aulast=Kuo |
| _version_ | 1818390020407427072 |
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| author | Tsung-Hang Kuo Chia-Chang Chuang Chin-Chung Tseng Ming-Yuan Hong Sheng-Hsiang Lin |
| author_facet | Tsung-Hang Kuo Chia-Chang Chuang Chin-Chung Tseng Ming-Yuan Hong Sheng-Hsiang Lin |
| author_sort | Tsung-Hang Kuo |
| collection | DOAJ |
| description | Objective: To identify the febrile characteristics and clinical presentations associated with fatality in hospitalized adult patients with dengue virus (DENV) infections.
Methods: A total of 289 adult hospitalized patients with laboratory-confirmed DENV infections were examined, of which 22 were fatal and 267 were non-fatal. A comparison of the clinical and laboratory characteristics was retrospectively conducted of the deceased and surviving individuals. Multivariate logistic regression and receiver operating characteristic curve analysis were performed to identify predictors of fatality.
Results: Fatal patients exhibited significantly more comorbidities, particularly renal and cardiac comorbidities, and they were, in general, older than control individuals (P<0.000 1). The results of logistic regression analysis showed that febrile duration of less than four days before arriving in the Emergency Department (OR=5.34; 95% CI: 1.39–20.6), episode of hypotension in the Emergency Department (OR=6.95; 95% CI: 2.40–20.1), and comorbidity with congestive heart failure (OR=11.26; 95% CI: 2.31–54.79) were all significantly associated with inpatient fatality due to DENV infection. The ROC curve analysis indicated that the final prognostic model yielded an area under the curve of 0.87 (95% CI: 0.79–0.97) for fatality.
Conclusions: The aforementioned clinical findings may help clinicians predict fatality among adult inpatients with DENV infection. |
| first_indexed | 2024-12-14T04:50:59Z |
| format | Article |
| id | doaj.art-04234ec02a934072a9d0b921623397b1 |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-12-14T04:50:59Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-04234ec02a934072a9d0b921623397b12022-12-21T23:16:32ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462020-01-0113730130710.4103/1995-7645.285829A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosisTsung-Hang KuoChia-Chang ChuangChin-Chung TsengMing-Yuan HongSheng-Hsiang LinObjective: To identify the febrile characteristics and clinical presentations associated with fatality in hospitalized adult patients with dengue virus (DENV) infections. Methods: A total of 289 adult hospitalized patients with laboratory-confirmed DENV infections were examined, of which 22 were fatal and 267 were non-fatal. A comparison of the clinical and laboratory characteristics was retrospectively conducted of the deceased and surviving individuals. Multivariate logistic regression and receiver operating characteristic curve analysis were performed to identify predictors of fatality. Results: Fatal patients exhibited significantly more comorbidities, particularly renal and cardiac comorbidities, and they were, in general, older than control individuals (P<0.000 1). The results of logistic regression analysis showed that febrile duration of less than four days before arriving in the Emergency Department (OR=5.34; 95% CI: 1.39–20.6), episode of hypotension in the Emergency Department (OR=6.95; 95% CI: 2.40–20.1), and comorbidity with congestive heart failure (OR=11.26; 95% CI: 2.31–54.79) were all significantly associated with inpatient fatality due to DENV infection. The ROC curve analysis indicated that the final prognostic model yielded an area under the curve of 0.87 (95% CI: 0.79–0.97) for fatality. Conclusions: The aforementioned clinical findings may help clinicians predict fatality among adult inpatients with DENV infection.http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=7;spage=301;epage=307;aulast=Kuodengue; hospitalized patient; adult; fatality; febrile duration; hypotension |
| spellingShingle | Tsung-Hang Kuo Chia-Chang Chuang Chin-Chung Tseng Ming-Yuan Hong Sheng-Hsiang Lin A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis Asian Pacific Journal of Tropical Medicine dengue; hospitalized patient; adult; fatality; febrile duration; hypotension |
| title | A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis |
| title_full | A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis |
| title_fullStr | A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis |
| title_full_unstemmed | A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis |
| title_short | A cohort study of hospitalized adult dengue patients with fatality in Taiwan: The elderly and febrile characteristics matter for prognosis |
| title_sort | cohort study of hospitalized adult dengue patients with fatality in taiwan the elderly and febrile characteristics matter for prognosis |
| topic | dengue; hospitalized patient; adult; fatality; febrile duration; hypotension |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=7;spage=301;epage=307;aulast=Kuo |
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