Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth

Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth

Abstract Background Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely understood. Prediction and evaluation of the risk of preterm birth is chal...

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Bibliographic Details
Main Authors: Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Rämet
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Medicine
Subjects:
Alpha-1-antitrypsin
Placenta
Proteomics
Preterm birth
SERPINA1
Trophoblast
Online Access:https://doi.org/10.1186/s12916-022-02339-8

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