Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
Abstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prev...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Malaria Journal |
| Online Access: | https://doi.org/10.1186/s12936-023-04458-w |
| _version_ | 1811171797287043072 |
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| author | Gillon Ilombe Thérèse Mpiempie Gauthier Mesia Junior R. Matangila Aimée M. Lulebo Vivi Maketa Baby Mabanzila Nicole M. Muela Flory T. Muanda Sylvie Linsuke Jean-Pierre van Geertruyden Pascal Lutumba |
| author_facet | Gillon Ilombe Thérèse Mpiempie Gauthier Mesia Junior R. Matangila Aimée M. Lulebo Vivi Maketa Baby Mabanzila Nicole M. Muela Flory T. Muanda Sylvie Linsuke Jean-Pierre van Geertruyden Pascal Lutumba |
| author_sort | Gillon Ilombe |
| collection | DOAJ |
| description | Abstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prevalence and predictors of AEs following the mass distribution of LLINs in the Kisantu Health Zone (KHZ), a high malaria-endemic region in the DRC. Methods A community-based cross-sectional study embedded was conducted within a randomized controlled trial (RCT) after the mass distribution of LLINs in 30 villages located in DRC KHZ. A three-stage sampling method was used without replacement to select 1790 children. Data was collected on adverse events (AEs) using a reporting form and information on demographics, nutritional status, and house characteristics. This was done using a structured questionnaire administered to household heads. Logistic regression models were used to identify predictors of AEs following the mass distribution of LLINs. Result In a total of 1790 children enrolled, 17.8% (95% CI 16.1–19.7) experienced AEs. The most common AEs were respiratory-related (61%). Around 60% of AEs occurred within 24 h of use, and 51% were resolved without treatment. Sleeping under deltamethrin LLINs (Adjusted OR, 95% CI 5.5 [3.8–8.0]) and zinc roofing (Adjusted OR, 95% CI 1.98 [1.1–3.57]) were associated with the risk of reporting an AE following the mass distribution of LLINs. Conclusion Approximately 1 out of 5 children had an AE within 24 h following LLIN use. These adverse events were often respiratory-related. LLINs and roofing types were associated with a higher risk of reporting AEs. However, further research using a robust study design is needed to confirm these findings. Future studies should design and implement interventions aiming to reduce AEs and improve compliance with LLINs. |
| first_indexed | 2024-04-10T17:21:11Z |
| format | Article |
| id | doaj.art-04265a0605774c4798b72ede4a52837e |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-10T17:21:11Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-04265a0605774c4798b72ede4a52837e2023-02-05T12:05:20ZengBMCMalaria Journal1475-28752023-02-012211810.1186/s12936-023-04458-wPrevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the CongoGillon Ilombe0Thérèse Mpiempie1Gauthier Mesia2Junior R. Matangila3Aimée M. Lulebo4Vivi Maketa5Baby Mabanzila6Nicole M. Muela7Flory T. Muanda8Sylvie Linsuke9Jean-Pierre van Geertruyden10Pascal Lutumba11Unit of Entomology, Department of Parasitology, National Institute of Biomedical ResearchUnit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of KinshasaUnit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of KinshasaDepartment of Tropical Medicine, Faculty of Medicine, University of KinshasaFaculty of Medicine, Public Health School, University of KinshasaDepartment of Tropical Medicine, Faculty of Medicine, University of KinshasaDepartment of Tropical Medicine, Faculty of Medicine, University of KinshasaExpanded on Inoculation Logistic Section, Ministry of Public Health KinshasaUnit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of KinshasaFaculty of Medicine, Global Health Institute, Antwerp UniversityFaculty of Medicine, Global Health Institute, Antwerp UniversityDepartment of Tropical Medicine, Faculty of Medicine, University of KinshasaAbstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prevalence and predictors of AEs following the mass distribution of LLINs in the Kisantu Health Zone (KHZ), a high malaria-endemic region in the DRC. Methods A community-based cross-sectional study embedded was conducted within a randomized controlled trial (RCT) after the mass distribution of LLINs in 30 villages located in DRC KHZ. A three-stage sampling method was used without replacement to select 1790 children. Data was collected on adverse events (AEs) using a reporting form and information on demographics, nutritional status, and house characteristics. This was done using a structured questionnaire administered to household heads. Logistic regression models were used to identify predictors of AEs following the mass distribution of LLINs. Result In a total of 1790 children enrolled, 17.8% (95% CI 16.1–19.7) experienced AEs. The most common AEs were respiratory-related (61%). Around 60% of AEs occurred within 24 h of use, and 51% were resolved without treatment. Sleeping under deltamethrin LLINs (Adjusted OR, 95% CI 5.5 [3.8–8.0]) and zinc roofing (Adjusted OR, 95% CI 1.98 [1.1–3.57]) were associated with the risk of reporting an AE following the mass distribution of LLINs. Conclusion Approximately 1 out of 5 children had an AE within 24 h following LLIN use. These adverse events were often respiratory-related. LLINs and roofing types were associated with a higher risk of reporting AEs. However, further research using a robust study design is needed to confirm these findings. Future studies should design and implement interventions aiming to reduce AEs and improve compliance with LLINs.https://doi.org/10.1186/s12936-023-04458-w |
| spellingShingle | Gillon Ilombe Thérèse Mpiempie Gauthier Mesia Junior R. Matangila Aimée M. Lulebo Vivi Maketa Baby Mabanzila Nicole M. Muela Flory T. Muanda Sylvie Linsuke Jean-Pierre van Geertruyden Pascal Lutumba Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo Malaria Journal |
| title | Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo |
| title_full | Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo |
| title_fullStr | Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo |
| title_full_unstemmed | Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo |
| title_short | Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo |
| title_sort | prevalence and predictors of adverse events following exposure to long lasting insecticidal nets used for malaria prevention a community based cross sectional study in the democratic republic of the congo |
| url | https://doi.org/10.1186/s12936-023-04458-w |
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