In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

Generation of bone marrow (BM) from embryonic stem cells (ESCs) promises to accelerate the development of future cell therapies for life-threatening disorders. However, such approach is limited by technical challenges to produce a mixture of functional BM progenitor cells able to replace all hematop...

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Bibliographic Details
Main Authors: Bingqiang Wen, Guolun Wang, Enhong Li, Olena A Kolesnichenko, Zhaowei Tu, Senad Divanovic, Tanya V Kalin, Vladimir V Kalinichenko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
interspecies chimeras
bone marrow
irradiation
mice
rats
blastocyst complementation
Online Access:https://elifesciences.org/articles/74018

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