Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice
Benzodiazepines (BDZ) are widely prescribed in the treatment of anxiety disorders associated to aging. Interestingly, whereas a reciprocal interaction between the GABAergic system and HPA axis has been evidenced, there is to our knowledge no direct evaluation of the impact of BDZ on both hippocampus...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00014/full |
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| author | Daniel eBeracochea Daniel eBeracochea Mathieu eCoutan Christophe eTronche Rodolphe eDorey Frédéric eChauveau Christophe ePierard |
| author_facet | Daniel eBeracochea Daniel eBeracochea Mathieu eCoutan Christophe eTronche Rodolphe eDorey Frédéric eChauveau Christophe ePierard |
| author_sort | Daniel eBeracochea |
| collection | DOAJ |
| description | Benzodiazepines (BDZ) are widely prescribed in the treatment of anxiety disorders associated to aging. Interestingly, whereas a reciprocal interaction between the GABAergic system and HPA axis has been evidenced, there is to our knowledge no direct evaluation of the impact of BDZ on both hippocampus (HPC) corticosterone concentrations and HPC-dependent memory in stressed middle-aged subjects. We showed previously that an acute stress induced in middle-aged mice severe memory impairments in a hippocampus-dependent task, and increased in parallel hippocampus corticosterone concentrations, as compared to non stressed middle-aged controls (Tronche et al., 2010). Based on these findings, the aims of the present study were to evidence the impact of diazepam (a positive allosteric modulator of the GABA-A receptor) on HPC glucocorticoids concentrations and in parallel on HPC-dependent memory in acutely stressed middle-aged mice.Microdialysis experiments showed an interaction between diazepam doses and corticosterone concentrations into the HPC. From 0.25 mg/kg to 0.5 mg/kg, diazepam dose-dependently reduces intra-HPC corticosterone concentrations and in parallel, dose-dependently increased hippocampal-dependent memory performance. In contrast, the highest (1.0mg/kg) diazepam dose induces a reduction in HPC corticosterone concentration, which was of greater magnitude as compared to the two other diazepam doses, but however decreased the hippocampal-dependent memory performance. In summary, our study provides first evidence that diazepam restores in stressed middle-aged animals the hippocampus-dependent response, in relation with HPC corticosterone concentrations. Overall, our data illustrate how stress and benzodiazepines could modulate cognitive functions depending on hippocampus activity. |
| first_indexed | 2024-04-13T13:34:22Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T13:34:22Z |
| publishDate | 2011-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-04298308b3ae498883ac4f54ffacbb5d2022-12-22T02:44:49ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532011-04-01510.3389/fnbeh.2011.000149156Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged miceDaniel eBeracochea0Daniel eBeracochea1Mathieu eCoutan2Christophe eTronche3Rodolphe eDorey4Frédéric eChauveau5Christophe ePierard6Institut de Neurosciences Cognitives et Integratives d'AquitaineInstitut de Neurosciences Cognitives et Integratives d'AquitaineInstitut de Recherche Biomédicale des ArméesInstitut de Recherche Biomédicale des ArméesInstitut de Recherche Biomédicale des ArméesInstitut de Recherche Biomédicale des ArméesInstitut de Recherche Biomédicale des ArméesBenzodiazepines (BDZ) are widely prescribed in the treatment of anxiety disorders associated to aging. Interestingly, whereas a reciprocal interaction between the GABAergic system and HPA axis has been evidenced, there is to our knowledge no direct evaluation of the impact of BDZ on both hippocampus (HPC) corticosterone concentrations and HPC-dependent memory in stressed middle-aged subjects. We showed previously that an acute stress induced in middle-aged mice severe memory impairments in a hippocampus-dependent task, and increased in parallel hippocampus corticosterone concentrations, as compared to non stressed middle-aged controls (Tronche et al., 2010). Based on these findings, the aims of the present study were to evidence the impact of diazepam (a positive allosteric modulator of the GABA-A receptor) on HPC glucocorticoids concentrations and in parallel on HPC-dependent memory in acutely stressed middle-aged mice.Microdialysis experiments showed an interaction between diazepam doses and corticosterone concentrations into the HPC. From 0.25 mg/kg to 0.5 mg/kg, diazepam dose-dependently reduces intra-HPC corticosterone concentrations and in parallel, dose-dependently increased hippocampal-dependent memory performance. In contrast, the highest (1.0mg/kg) diazepam dose induces a reduction in HPC corticosterone concentration, which was of greater magnitude as compared to the two other diazepam doses, but however decreased the hippocampal-dependent memory performance. In summary, our study provides first evidence that diazepam restores in stressed middle-aged animals the hippocampus-dependent response, in relation with HPC corticosterone concentrations. Overall, our data illustrate how stress and benzodiazepines could modulate cognitive functions depending on hippocampus activity.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00014/fullAgingBenzodiazepinesCorticosteroneGlucocorticoidsMemoryMice |
| spellingShingle | Daniel eBeracochea Daniel eBeracochea Mathieu eCoutan Christophe eTronche Rodolphe eDorey Frédéric eChauveau Christophe ePierard Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice Frontiers in Behavioral Neuroscience Aging Benzodiazepines Corticosterone Glucocorticoids Memory Mice |
| title | Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice |
| title_full | Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice |
| title_fullStr | Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice |
| title_full_unstemmed | Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice |
| title_short | Interaction between diazepam and hippocampal corticosterone after acute stress: impact on memory in middle-aged mice |
| title_sort | interaction between diazepam and hippocampal corticosterone after acute stress impact on memory in middle aged mice |
| topic | Aging Benzodiazepines Corticosterone Glucocorticoids Memory Mice |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00014/full |
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