Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in <i>Candida glabrata</i>

Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in <i>Candida glabrata</i>

In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in <i>Candida glabrata</i> by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with <i>S. cerevisiae</i> counterparts, the proteins are predicted to catalyz...

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Bibliographic Details
Main Authors: Garima Shahi, Mohit Kumar, Nitesh Kumar Khandelwal, Atanu Banerjee, Parijat Sarkar, Sonam Kumari, Brooke D. Esquivel, Neeraj Chauhan, Amitabha Chattopadhyay, Theodore C. White, Naseem A. Gaur, Ashutosh Singh, Rajendra Prasad
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Journal of Fungi
Subjects:
<i>Candida glabrata</i>
sphingolipids
inositolphosphorylceramide
lipidomics
drug resistance
virulence
Online Access:https://www.mdpi.com/2309-608X/8/7/651

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