Generalized Lichen Planus-like Eruption Related to Trimebutine
Trimebutine is a spasmolytic agent with antimuscarinic effects that is used for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders. Lichenoid drug eruptions (LDE) to trimebutine maleate have not been previously reported. Here we present the case of a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2020-11-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/2103 |
| _version_ | 1818426947256975360 |
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| author | Dimitra Koumaki Vasiliki Koumaki Alexander Katoulis Sotirios Boumpoucheropoulos George Evangelou Maria Stefanidou Konstantinos Krasagakis |
| author_facet | Dimitra Koumaki Vasiliki Koumaki Alexander Katoulis Sotirios Boumpoucheropoulos George Evangelou Maria Stefanidou Konstantinos Krasagakis |
| author_sort | Dimitra Koumaki |
| collection | DOAJ |
| description | Trimebutine is a spasmolytic agent with antimuscarinic effects that is used for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders. Lichenoid drug eruptions (LDE) to trimebutine maleate have not been previously reported. Here we present the case of a 50-year-old male patient who developed an extensive lichenoid eruption on his upper and lower extremities and trunk 4 weeks after starting treatment with trimebutine maleate 300 mg once daily for IBS. Two months after discontinuation of the drug and administration of topical treatment with emollients and corticosteroids, the LDE cleared completely with no recurrence. The diagnosis of LDE due to trimebutine was made, based upon the clinical features resembling lichen planus, the histological findings of interface dermatitis, the evidence of a temporal relationship between drug intake and the development of skin lesions, and resolution upon discontinuation of the drug. To the best of the authors’ knowledge, LDE following trimebutine maleate intake has not been previously reported. Management of trimebutine-induced LDE includes withdrawal of the causative agent and treatment with potent topical corticosteroids. |
| first_indexed | 2024-12-14T14:37:55Z |
| format | Article |
| id | doaj.art-042f3db6b0974b258ee497d6f855d032 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-14T14:37:55Z |
| publishDate | 2020-11-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-042f3db6b0974b258ee497d6f855d0322022-12-21T22:57:30ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-11-0110.12890/2020_0021031719Generalized Lichen Planus-like Eruption Related to TrimebutineDimitra Koumaki0Vasiliki Koumaki1Alexander Katoulis2Sotirios Boumpoucheropoulos3George Evangelou4Maria Stefanidou5Konstantinos Krasagakis6Dermatology Department, University Hospital of Heraklion, Heraklion, Crete, GreeceMicrobiology Department, Medical School of Athens, Athens, Greece2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, “Attikon” General University Hospital, Athens, Greece Medical Oncology Department, Agioi Anargyroi General Oncological Hospital of Kifissia, Athens, GreeceDermatology Department, University Hospital of Heraklion, Heraklion, Crete, GreeceDermatology Department, University Hospital of Heraklion, Heraklion, Crete, GreeceDermatology Department, University Hospital of Heraklion, Heraklion, Crete, GreeceTrimebutine is a spasmolytic agent with antimuscarinic effects that is used for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders. Lichenoid drug eruptions (LDE) to trimebutine maleate have not been previously reported. Here we present the case of a 50-year-old male patient who developed an extensive lichenoid eruption on his upper and lower extremities and trunk 4 weeks after starting treatment with trimebutine maleate 300 mg once daily for IBS. Two months after discontinuation of the drug and administration of topical treatment with emollients and corticosteroids, the LDE cleared completely with no recurrence. The diagnosis of LDE due to trimebutine was made, based upon the clinical features resembling lichen planus, the histological findings of interface dermatitis, the evidence of a temporal relationship between drug intake and the development of skin lesions, and resolution upon discontinuation of the drug. To the best of the authors’ knowledge, LDE following trimebutine maleate intake has not been previously reported. Management of trimebutine-induced LDE includes withdrawal of the causative agent and treatment with potent topical corticosteroids.https://www.ejcrim.com/index.php/EJCRIM/article/view/2103trimebutine maleate lichenoid drug eruptionlichen planuscutaneous adverse reaction |
| spellingShingle | Dimitra Koumaki Vasiliki Koumaki Alexander Katoulis Sotirios Boumpoucheropoulos George Evangelou Maria Stefanidou Konstantinos Krasagakis Generalized Lichen Planus-like Eruption Related to Trimebutine European Journal of Case Reports in Internal Medicine trimebutine maleate lichenoid drug eruption lichen planus cutaneous adverse reaction |
| title | Generalized Lichen Planus-like Eruption Related to Trimebutine |
| title_full | Generalized Lichen Planus-like Eruption Related to Trimebutine |
| title_fullStr | Generalized Lichen Planus-like Eruption Related to Trimebutine |
| title_full_unstemmed | Generalized Lichen Planus-like Eruption Related to Trimebutine |
| title_short | Generalized Lichen Planus-like Eruption Related to Trimebutine |
| title_sort | generalized lichen planus like eruption related to trimebutine |
| topic | trimebutine maleate lichenoid drug eruption lichen planus cutaneous adverse reaction |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/2103 |
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