Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications
In the present study, nickel ferrite (NiFe<sub>2</sub>O<sub>4</sub>)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles revealed...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/13/2286 |
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| author | Faten Eshrati Yeganeh Amir Eshrati Yeganeh Bahareh Farasati Far Afsoun Mansouri Belay Zeleke Sibuh Saravanan Krishnan Soumya Pandit Walaa F. Alsanie Vijay Kumar Thakur Piyush Kumar Gupta |
| author_facet | Faten Eshrati Yeganeh Amir Eshrati Yeganeh Bahareh Farasati Far Afsoun Mansouri Belay Zeleke Sibuh Saravanan Krishnan Soumya Pandit Walaa F. Alsanie Vijay Kumar Thakur Piyush Kumar Gupta |
| author_sort | Faten Eshrati Yeganeh |
| collection | DOAJ |
| description | In the present study, nickel ferrite (NiFe<sub>2</sub>O<sub>4</sub>)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles also showed strong antibacterial activity against different bacterial pathogens. |
| first_indexed | 2024-03-09T12:41:28Z |
| format | Article |
| id | doaj.art-0430d81f103a44a28fc6c42c7dc83b1c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T12:41:28Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-0430d81f103a44a28fc6c42c7dc83b1c2023-11-30T22:17:03ZengMDPI AGNanomaterials2079-49912022-07-011213228610.3390/nano12132286Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial ApplicationsFaten Eshrati Yeganeh0Amir Eshrati Yeganeh1Bahareh Farasati Far2Afsoun Mansouri3Belay Zeleke Sibuh4Saravanan Krishnan5Soumya Pandit6Walaa F. Alsanie7Vijay Kumar Thakur8Piyush Kumar Gupta9Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893855, IranDepartment of Microbiology, Noor Dahesh Institute of Higher Education, Meymeh 45789427600, IranDepartment of Chemistry, Iran University of Science and Technology, Tehran 1684613114, IranSchool of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran 1477893855, IranDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, IndiaCreative Carbon Labs Pvt. Ltd., Chennai 600113, Tamil Nadu, IndiaDepartment of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, IndiaDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi ArabiaBiorefining and Advanced Materials Research Centre, Scotland’s Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UKDepartment of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, IndiaIn the present study, nickel ferrite (NiFe<sub>2</sub>O<sub>4</sub>)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles also showed strong antibacterial activity against different bacterial pathogens.https://www.mdpi.com/2079-4991/12/13/2286methionine-NiFe<sub>2</sub>O<sub>4</sub> nanoparticlesdrug releaseantibacterialanticancercytotoxicity |
| spellingShingle | Faten Eshrati Yeganeh Amir Eshrati Yeganeh Bahareh Farasati Far Afsoun Mansouri Belay Zeleke Sibuh Saravanan Krishnan Soumya Pandit Walaa F. Alsanie Vijay Kumar Thakur Piyush Kumar Gupta Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications Nanomaterials methionine-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles drug release antibacterial anticancer cytotoxicity |
| title | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications |
| title_full | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications |
| title_fullStr | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications |
| title_full_unstemmed | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications |
| title_short | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications |
| title_sort | synthesis and characterization of tetracycline loaded methionine coated nife sub 2 sub o sub 4 sub nanoparticles for anticancer and antibacterial applications |
| topic | methionine-NiFe<sub>2</sub>O<sub>4</sub> nanoparticles drug release antibacterial anticancer cytotoxicity |
| url | https://www.mdpi.com/2079-4991/12/13/2286 |
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