Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination
ABSTRACTHuman infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry. Carefully analysis of H7N9 viruses in poultry that have sub-optimal immunity may provide a unique opportunity to witn...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2343912 |
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| author | Yujie Hou Guohua Deng Pengfei Cui Xianying Zeng Bin Li Dongxue Wang Xinwen He Cheng Yan Yaping Zhang Jiongjie Li Jinming Ma Yanbing Li Xiurong Wang Guobin Tian Huihui Kong Lijie Tang Yasuo Suzuki Jianzhong Shi Hualan Chen |
| author_facet | Yujie Hou Guohua Deng Pengfei Cui Xianying Zeng Bin Li Dongxue Wang Xinwen He Cheng Yan Yaping Zhang Jiongjie Li Jinming Ma Yanbing Li Xiurong Wang Guobin Tian Huihui Kong Lijie Tang Yasuo Suzuki Jianzhong Shi Hualan Chen |
| author_sort | Yujie Hou |
| collection | DOAJ |
| description | ABSTRACTHuman infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry. Carefully analysis of H7N9 viruses in poultry that have sub-optimal immunity may provide a unique opportunity to witness the evolution of highly pathogenic avian influenza virus in the context of vaccination. Between January 2020 and June 2023, we isolated 16 H7N9 viruses from samples we collected during surveillance and samples that were sent to us for disease diagnosis. Genetic analysis indicated that these viruses belonged to a single genotype previously detected in poultry. Antigenic analysis indicated that 12 of the 16 viruses were antigenically close to the H7-Re4 vaccine virus that has been used since January 2022, and the other four viruses showed reduced reactivity with the vaccine. Animal studies indicated that all 16 viruses were nonlethal in mice, and four of six viruses showed reduced virulence in chickens upon intranasally inoculation. Importantly, the H7N9 viruses detected in this study exclusively bound to the avian-type receptors, having lost the capacity to bind to human-type receptors. Our study shows that vaccination slows the evolution of H7N9 virus by preventing its reassortment with other viruses and eliminates a harmful characteristic of H7N9 virus, namely its ability to bind to human-type receptors. |
| first_indexed | 2024-04-24T08:05:41Z |
| format | Article |
| id | doaj.art-0432f99b38924265a56502b36604addd |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2025-03-22T03:19:22Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-0432f99b38924265a56502b36604addd2024-04-29T21:15:56ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2343912Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccinationYujie Hou0Guohua Deng1Pengfei Cui2Xianying Zeng3Bin Li4Dongxue Wang5Xinwen He6Cheng Yan7Yaping Zhang8Jiongjie Li9Jinming Ma10Yanbing Li11Xiurong Wang12Guobin Tian13Huihui Kong14Lijie Tang15Yasuo Suzuki16Jianzhong Shi17Hualan Chen18State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, People’s Republic of ChinaDepartment of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, JapanState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaABSTRACTHuman infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry. Carefully analysis of H7N9 viruses in poultry that have sub-optimal immunity may provide a unique opportunity to witness the evolution of highly pathogenic avian influenza virus in the context of vaccination. Between January 2020 and June 2023, we isolated 16 H7N9 viruses from samples we collected during surveillance and samples that were sent to us for disease diagnosis. Genetic analysis indicated that these viruses belonged to a single genotype previously detected in poultry. Antigenic analysis indicated that 12 of the 16 viruses were antigenically close to the H7-Re4 vaccine virus that has been used since January 2022, and the other four viruses showed reduced reactivity with the vaccine. Animal studies indicated that all 16 viruses were nonlethal in mice, and four of six viruses showed reduced virulence in chickens upon intranasally inoculation. Importantly, the H7N9 viruses detected in this study exclusively bound to the avian-type receptors, having lost the capacity to bind to human-type receptors. Our study shows that vaccination slows the evolution of H7N9 virus by preventing its reassortment with other viruses and eliminates a harmful characteristic of H7N9 virus, namely its ability to bind to human-type receptors.https://www.tandfonline.com/doi/10.1080/22221751.2024.2343912Avian influenza virus; H7N9; evolution; receptor-binding properties; pathogenicity; antigenicity |
| spellingShingle | Yujie Hou Guohua Deng Pengfei Cui Xianying Zeng Bin Li Dongxue Wang Xinwen He Cheng Yan Yaping Zhang Jiongjie Li Jinming Ma Yanbing Li Xiurong Wang Guobin Tian Huihui Kong Lijie Tang Yasuo Suzuki Jianzhong Shi Hualan Chen Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination Emerging Microbes and Infections Avian influenza virus; H7N9; evolution; receptor-binding properties; pathogenicity; antigenicity |
| title | Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination |
| title_full | Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination |
| title_fullStr | Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination |
| title_full_unstemmed | Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination |
| title_short | Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination |
| title_sort | evolution of h7n9 highly pathogenic avian influenza virus in the context of vaccination |
| topic | Avian influenza virus; H7N9; evolution; receptor-binding properties; pathogenicity; antigenicity |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2343912 |
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