Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri
“Location, location, and location”: according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00682/full |
| _version_ | 1818693136590831616 |
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| author | Silvia Piconese Silvia Piconese Silvia Campello Ambra Natalini Ambra Natalini |
| author_facet | Silvia Piconese Silvia Piconese Silvia Campello Ambra Natalini Ambra Natalini |
| author_sort | Silvia Piconese |
| collection | DOAJ |
| description | “Location, location, and location”: according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to determine immunity to pathogens, and tumors. If location matters also for human beings, the inspiring environment of Capri Island has contributed to the success of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology focused on “T cell memory,” held in Anacapri from October 12, 2018 to October 15, 2018. In this minireview, we would like to highlight some novel concepts about T cell migration and residency and discuss their implications in relation to recent advances in the field, including the mechanisms regulating compartmentalization and cell cycle entry of T cells during activation, the role of mitochondrial metabolism in T cell movement, and the residency of regulatory T cells. |
| first_indexed | 2024-12-17T13:08:53Z |
| format | Article |
| id | doaj.art-0434cfa0c7d44df5afdca0f5ece9bbff |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T13:08:53Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0434cfa0c7d44df5afdca0f5ece9bbff2022-12-21T21:47:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00682525755Recirculation and Residency of T Cells and Tregs: Lessons Learnt in AnacapriSilvia Piconese0Silvia Piconese1Silvia Campello2Ambra Natalini3Ambra Natalini4Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Rome, ItalyLaboratory Affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, ItalyDepartment of Biology, University of Rome Tor Vergata, Rome, ItalyInstitute of Molecular Biology and Pathology, National Research Council (CNR), Rome, ItalyDipartimento di Medicina Molecolare (DMM), Sapienza Università di Roma, Rome, Italy“Location, location, and location”: according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to determine immunity to pathogens, and tumors. If location matters also for human beings, the inspiring environment of Capri Island has contributed to the success of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology focused on “T cell memory,” held in Anacapri from October 12, 2018 to October 15, 2018. In this minireview, we would like to highlight some novel concepts about T cell migration and residency and discuss their implications in relation to recent advances in the field, including the mechanisms regulating compartmentalization and cell cycle entry of T cells during activation, the role of mitochondrial metabolism in T cell movement, and the residency of regulatory T cells.https://www.frontiersin.org/article/10.3389/fimmu.2020.00682/fullT cellsTregscell migrationcell cyclerecirculation |
| spellingShingle | Silvia Piconese Silvia Piconese Silvia Campello Ambra Natalini Ambra Natalini Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri Frontiers in Immunology T cells Tregs cell migration cell cycle recirculation |
| title | Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri |
| title_full | Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri |
| title_fullStr | Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri |
| title_full_unstemmed | Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri |
| title_short | Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri |
| title_sort | recirculation and residency of t cells and tregs lessons learnt in anacapri |
| topic | T cells Tregs cell migration cell cycle recirculation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00682/full |
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