Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks
A subset of patients with Parkinson’s disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00279/full |
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| author | Marit F. L. Ruitenberg Tina Wu Bruno B. Averbeck Kelvin L. Chou Vincent Koppelmans Rachael D. Seidler Rachael D. Seidler |
| author_facet | Marit F. L. Ruitenberg Tina Wu Bruno B. Averbeck Kelvin L. Chou Vincent Koppelmans Rachael D. Seidler Rachael D. Seidler |
| author_sort | Marit F. L. Ruitenberg |
| collection | DOAJ |
| description | A subset of patients with Parkinson’s disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control disorders (ICDs) in PD. We collected resting-state functional connectivity and structural MRI data from 21 PD patients with ICDs and 30 patients without such disorders. To assess impulsivity, all patients completed the Barratt Impulsiveness Scale and performed an information-gathering task. MRI results demonstrated substantial differences in neural characteristics between PD patients with and without ICDs. Results showed that impulsivity was linked to alterations in affective basal ganglia circuitries. Specifically, reduced frontal–striatal connectivity and GPe volume were associated with more impulsivity. We suggest that these changes affect decision making and result in a preference for risky or inappropriate actions. Results further showed that impulsivity was linked to alterations in sensorimotor striatal networks. Enhanced connectivity within this network and larger putamen volume were associated with more impulsivity. We propose that these changes affect sensorimotor processing such that patients have a greater propensity to act. Our findings suggest that the two mechanisms jointly contribute to impulsive behaviors in PD. |
| first_indexed | 2024-12-20T07:42:22Z |
| format | Article |
| id | doaj.art-0437f707b7024d2da676e6fea9597310 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T07:42:22Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0437f707b7024d2da676e6fea95973102022-12-21T19:48:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-04-01910.3389/fneur.2018.00279354214Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal NetworksMarit F. L. Ruitenberg0Tina Wu1Bruno B. Averbeck2Kelvin L. Chou3Vincent Koppelmans4Rachael D. Seidler5Rachael D. Seidler6School of Kinesiology, University of Michigan, Ann Arbor, MI, United StatesSchool of Kinesiology, University of Michigan, Ann Arbor, MI, United StatesNational Institute of Mental Health, Bethesda, MD, United StatesDepartment of Neurology, University of Michigan Health System, Ann Arbor, MI, United StatesSchool of Kinesiology, University of Michigan, Ann Arbor, MI, United StatesSchool of Kinesiology, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, United StatesA subset of patients with Parkinson’s disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control disorders (ICDs) in PD. We collected resting-state functional connectivity and structural MRI data from 21 PD patients with ICDs and 30 patients without such disorders. To assess impulsivity, all patients completed the Barratt Impulsiveness Scale and performed an information-gathering task. MRI results demonstrated substantial differences in neural characteristics between PD patients with and without ICDs. Results showed that impulsivity was linked to alterations in affective basal ganglia circuitries. Specifically, reduced frontal–striatal connectivity and GPe volume were associated with more impulsivity. We suggest that these changes affect decision making and result in a preference for risky or inappropriate actions. Results further showed that impulsivity was linked to alterations in sensorimotor striatal networks. Enhanced connectivity within this network and larger putamen volume were associated with more impulsivity. We propose that these changes affect sensorimotor processing such that patients have a greater propensity to act. Our findings suggest that the two mechanisms jointly contribute to impulsive behaviors in PD.http://journal.frontiersin.org/article/10.3389/fneur.2018.00279/fullParkinson’s diseaseimpulsivitybasal gangliaaffective striatumsensorimotor striatum |
| spellingShingle | Marit F. L. Ruitenberg Tina Wu Bruno B. Averbeck Kelvin L. Chou Vincent Koppelmans Rachael D. Seidler Rachael D. Seidler Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks Frontiers in Neurology Parkinson’s disease impulsivity basal ganglia affective striatum sensorimotor striatum |
| title | Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks |
| title_full | Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks |
| title_fullStr | Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks |
| title_full_unstemmed | Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks |
| title_short | Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks |
| title_sort | impulsivity in parkinson s disease is associated with alterations in affective and sensorimotor striatal networks |
| topic | Parkinson’s disease impulsivity basal ganglia affective striatum sensorimotor striatum |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00279/full |
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