Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort
The combined effects of comorbidities can cause cancer incidence, while the effects of individual conditions, alone, might not. This study was conducted to investigate the joint impact of comorbidities on cancer incidence. The dietary score for energy-adjusted intake was calculated by applying a Gau...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/7/1834 |
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| author | Tung Hoang Jeonghee Lee Jeongseon Kim |
| author_facet | Tung Hoang Jeonghee Lee Jeongseon Kim |
| author_sort | Tung Hoang |
| collection | DOAJ |
| description | The combined effects of comorbidities can cause cancer incidence, while the effects of individual conditions, alone, might not. This study was conducted to investigate the joint impact of comorbidities on cancer incidence. The dietary score for energy-adjusted intake was calculated by applying a Gaussian graphical model and was then categorized into tertiles representing light, normal, and heavy eating behaviors. The risk point for cancer, according to the statuses of blood pressure, total cholesterol, fasting glucose, and glomerular filtration rate was computed from a Cox proportional hazard model adjusted for demographics and eating behavior. The comorbidity risk score was defined as the sum of the risk points for four comorbidity markers. We finally quantified the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the strata of the comorbidity risk score and cancer incidence. A total of 13,644 subjects were recruited from the Cancer Screenee Cohort from 2007–2014. The comorbidity risk score was associated with cancer incidence in a dose-dependent manner (HR = 2.15, 95% CI = 1.39, 3.31 for those scoring 16–30 vs. those scoring 0–8, <i>P</i>-trend < 0.001). Subgroup analysis still showed significant dose-dependent relationships (HR = 2.39, 95% CI = 1.18, 4.84 for males and HR = 1.99, 95% CI = 1.11, 3.59 for females, <i>P</i>-trend < 0.05). In summary, there was a dose-dependent impact of comorbidities on cancer incidence; Highlights: Previous studies have generally reported that hypertension, hypercholesterolemia, diabetes, and chronic kidney disease might predispose patients to cancer. Combining these chronic diseases into a single score, this study found a dose-dependent association between the data-driven comorbidity risk score and cancer incidence. |
| first_indexed | 2024-03-10T18:37:08Z |
| format | Article |
| id | doaj.art-0437fec34a664b28883e7e74633631f7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:37:08Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0437fec34a664b28883e7e74633631f72023-11-20T06:09:09ZengMDPI AGCancers2072-66942020-07-01127183410.3390/cancers12071834Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee CohortTung Hoang0Jeonghee Lee1Jeongseon Kim2Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, KoreaDepartment of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, KoreaDepartment of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, KoreaThe combined effects of comorbidities can cause cancer incidence, while the effects of individual conditions, alone, might not. This study was conducted to investigate the joint impact of comorbidities on cancer incidence. The dietary score for energy-adjusted intake was calculated by applying a Gaussian graphical model and was then categorized into tertiles representing light, normal, and heavy eating behaviors. The risk point for cancer, according to the statuses of blood pressure, total cholesterol, fasting glucose, and glomerular filtration rate was computed from a Cox proportional hazard model adjusted for demographics and eating behavior. The comorbidity risk score was defined as the sum of the risk points for four comorbidity markers. We finally quantified the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the strata of the comorbidity risk score and cancer incidence. A total of 13,644 subjects were recruited from the Cancer Screenee Cohort from 2007–2014. The comorbidity risk score was associated with cancer incidence in a dose-dependent manner (HR = 2.15, 95% CI = 1.39, 3.31 for those scoring 16–30 vs. those scoring 0–8, <i>P</i>-trend < 0.001). Subgroup analysis still showed significant dose-dependent relationships (HR = 2.39, 95% CI = 1.18, 4.84 for males and HR = 1.99, 95% CI = 1.11, 3.59 for females, <i>P</i>-trend < 0.05). In summary, there was a dose-dependent impact of comorbidities on cancer incidence; Highlights: Previous studies have generally reported that hypertension, hypercholesterolemia, diabetes, and chronic kidney disease might predispose patients to cancer. Combining these chronic diseases into a single score, this study found a dose-dependent association between the data-driven comorbidity risk score and cancer incidence.https://www.mdpi.com/2072-6694/12/7/1834comorbidity risk scoredietary scorecancer incidenceGaussian graphical model |
| spellingShingle | Tung Hoang Jeonghee Lee Jeongseon Kim Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort Cancers comorbidity risk score dietary score cancer incidence Gaussian graphical model |
| title | Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort |
| title_full | Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort |
| title_fullStr | Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort |
| title_full_unstemmed | Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort |
| title_short | Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort |
| title_sort | comorbidity risk score in association with cancer incidence results from a cancer screenee cohort |
| topic | comorbidity risk score dietary score cancer incidence Gaussian graphical model |
| url | https://www.mdpi.com/2072-6694/12/7/1834 |
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