On peroxide antimalarials
Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure–activity relationship of this kind of antimalarials. The tetraoxanes 2–5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptib...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2007-12-01
|
| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/JSCS/Vol72/No12/JSCS_V72_No12-03.pdf |
| _version_ | 1818833118373609472 |
|---|---|
| author | IGOR OPSENICA DEJAN OPSENICA MILKA JADRANIN KIRSTEN S. SMITH WILBUR K. MILHOUS MANOLIS STRATAKIS BOGDAN ŠOLAJA |
| author_facet | IGOR OPSENICA DEJAN OPSENICA MILKA JADRANIN KIRSTEN S. SMITH WILBUR K. MILHOUS MANOLIS STRATAKIS BOGDAN ŠOLAJA |
| author_sort | IGOR OPSENICA |
| collection | DOAJ |
| description | Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure–activity relationship of this kind of antimalarials. The tetraoxanes 2–5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized. |
| first_indexed | 2024-12-19T02:13:50Z |
| format | Article |
| id | doaj.art-043a0b998e2749609c8194dc9750d498 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-19T02:13:50Z |
| publishDate | 2007-12-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-043a0b998e2749609c8194dc9750d4982022-12-21T20:40:30ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392007-12-01721211811190On peroxide antimalarialsIGOR OPSENICADEJAN OPSENICAMILKA JADRANINKIRSTEN S. SMITHWILBUR K. MILHOUSMANOLIS STRATAKISBOGDAN ŠOLAJASeveral dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure–activity relationship of this kind of antimalarials. The tetraoxanes 2–5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.http://www.shd.org.yu/JSCS/Vol72/No12/JSCS_V72_No12-03.pdfmixed tetraoxanesendoperoxidesmalariaP. falciparum |
| spellingShingle | IGOR OPSENICA DEJAN OPSENICA MILKA JADRANIN KIRSTEN S. SMITH WILBUR K. MILHOUS MANOLIS STRATAKIS BOGDAN ŠOLAJA On peroxide antimalarials Journal of the Serbian Chemical Society mixed tetraoxanes endoperoxides malaria P. falciparum |
| title | On peroxide antimalarials |
| title_full | On peroxide antimalarials |
| title_fullStr | On peroxide antimalarials |
| title_full_unstemmed | On peroxide antimalarials |
| title_short | On peroxide antimalarials |
| title_sort | on peroxide antimalarials |
| topic | mixed tetraoxanes endoperoxides malaria P. falciparum |
| url | http://www.shd.org.yu/JSCS/Vol72/No12/JSCS_V72_No12-03.pdf |
| work_keys_str_mv | AT igoropsenica onperoxideantimalarials AT dejanopsenica onperoxideantimalarials AT milkajadranin onperoxideantimalarials AT kirstenssmith onperoxideantimalarials AT wilburkmilhous onperoxideantimalarials AT manolisstratakis onperoxideantimalarials AT bogdansolaja onperoxideantimalarials |