Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
The exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorde...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26720-y |
| _version_ | 1827983302604095488 |
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| author | Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wesley De Neve Wim Vranken Nico Callewaert |
| author_facet | Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wesley De Neve Wim Vranken Nico Callewaert |
| author_sort | Morgane Boone |
| collection | DOAJ |
| description | The exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorder. |
| first_indexed | 2024-04-09T22:45:28Z |
| format | Article |
| id | doaj.art-043a1799d9594a9ab4b4cd01c3c5aabe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:45:28Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-043a1799d9594a9ab4b4cd01c3c5aabe2023-03-22T11:49:49ZengNature PortfolioNature Communications2041-17232021-11-0112111610.1038/s41467-021-26720-yMassively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transitMorgane Boone0Pathmanaban Ramasamy1Jasper Zuallaert2Robbin Bouwmeester3Berre Van Moer4Davy Maddelein5Demet Turan6Niels Hulstaert7Hannah Eeckhaut8Elien Vandermarliere9Lennart Martens10Sven Degroeve11Wesley De Neve12Wim Vranken13Nico Callewaert14Center for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Medical Biotechnology, VIBCenter for Biotech Data Science, Ghent University Global CampusStructural Biology Brussels, VUBCenter for Medical Biotechnology, VIBThe exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorder.https://doi.org/10.1038/s41467-021-26720-y |
| spellingShingle | Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wesley De Neve Wim Vranken Nico Callewaert Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit Nature Communications |
| title | Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit |
| title_full | Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit |
| title_fullStr | Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit |
| title_full_unstemmed | Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit |
| title_short | Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit |
| title_sort | massively parallel interrogation of protein fragment secretability using secrify reveals features influencing secretory system transit |
| url | https://doi.org/10.1038/s41467-021-26720-y |
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