Exosomes derived from mesenchymal stromal cells exert a therapeutic effect on hypoxia-induced pulmonary hypertension by modulating the YAP1/SPP1 signaling pathway

Exosomes derived from mesenchymal stromal cells exert a therapeutic effect on hypoxia-induced pulmonary hypertension by modulating the YAP1/SPP1 signaling pathway

Objective: Hypoxic pulmonary hypertension (HPH) is a progressive and life-threatening disease characterized by perivascular inflammation, pulmonary vascular remodeling, and occlusion. Mesenchymal stromal cell-derived exosomes (MSC-exo) have emerged as potential therapeutic agents due to their role i...

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Bibliographic Details
Main Authors:	Yao-Xin Chen, Zhi-Hua Deng, Xue-Gao, Qiang-Du, Juan-Yin, Guang-Hua Chen, Jun-Gen Li, Yi-Ming Zhao, Hao-Tian Zhang, Guo-Xing Zhang, Jin-Xian Qian
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Hypoxic pulmonary hypertension (HPH) Mesenchymal Stem Cell (MSC) Exosome Pulmonary artery smooth muscle cell (PASMC) Proliferation YAP1/SPP1 signaling pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223016141

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