Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
Jinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/exercise-induced-changes-in-stress-hormones-and-cell-adhesion-molecule-peer-reviewed-article-JIR |
| _version_ | 1818845486654685184 |
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| author | Park J Willoughby DS Song JJ Leutholtz BC Koh Y |
| author_facet | Park J Willoughby DS Song JJ Leutholtz BC Koh Y |
| author_sort | Park J |
| collection | DOAJ |
| description | Jinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University, Waco, TX, USA Purpose: The current study examined the relationship between exercise-induced changes in stress hormones (epinephrine, norepinephrine, and cortisol) and vascular inflammatory markers (soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial selectin [sE-selectin], and soluble vascular adhesion molecule-1 [sVCAM-1]) in obese men over a 24-hour period following exercise at lower and higher intensity.Patients and methods: Fifteen physically inactive, obese, college-aged men performed a single bout of cycling exercise at lower and higher intensities (lower intensity: 50% of maximal heart rate, and higher intensity: 80% of maximal heart rate) in random order. Overnight fasting blood samples were collected at baseline, immediately postexercise (IPE), 1-hour PE (1-h PE), and 24-hour PE. Changes in stress hormones and inflammatory markers were analyzed with a repeated-measures analysis of variance using Bonferroni multiple comparisons and a linear regression analysis (p<0.05).Results: sICAM-1, sVCAM-1, epinephrine, and norepinephrine did not change over time, while sE-selectin was significantly lower at 1-h PE (10.25±1.07 ng/mL, p=0.04) than at baseline (12.22±1.39 ng/mL). Cortisol and sICAM-1 were negatively related at 1-h PE following lower-intensity exercise (r2=0.34, p=0.02), whereas cortisol and sVCAM-1 were positively related at IPE following higher-intensity exercise (r2=0.36, p=0.02).Conclusion: Regardless of intensity, an acute bout of aerobic exercise may lower sE-selectin in sedentary obese men. Responses of cortisol are dependent on exercise intensity, and cortisol may be a key stress hormone playing a major role in regulating sICAM-1 and sVCAM-1. Keywords: vascular inflammation, ICAM-1, VACM-1, E-selectin, stress hormones, exercise intensity |
| first_indexed | 2024-12-19T05:30:26Z |
| format | Article |
| id | doaj.art-043ebb1a166542e59078188528c6080e |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-12-19T05:30:26Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-043ebb1a166542e59078188528c6080e2022-12-21T20:34:15ZengDove Medical PressJournal of Inflammation Research1178-70312018-03-01Volume 11697537000Exercise-induced changes in stress hormones and cell adhesion molecules in obese menPark JWilloughby DSSong JJLeutholtz BCKoh YJinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University, Waco, TX, USA Purpose: The current study examined the relationship between exercise-induced changes in stress hormones (epinephrine, norepinephrine, and cortisol) and vascular inflammatory markers (soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial selectin [sE-selectin], and soluble vascular adhesion molecule-1 [sVCAM-1]) in obese men over a 24-hour period following exercise at lower and higher intensity.Patients and methods: Fifteen physically inactive, obese, college-aged men performed a single bout of cycling exercise at lower and higher intensities (lower intensity: 50% of maximal heart rate, and higher intensity: 80% of maximal heart rate) in random order. Overnight fasting blood samples were collected at baseline, immediately postexercise (IPE), 1-hour PE (1-h PE), and 24-hour PE. Changes in stress hormones and inflammatory markers were analyzed with a repeated-measures analysis of variance using Bonferroni multiple comparisons and a linear regression analysis (p<0.05).Results: sICAM-1, sVCAM-1, epinephrine, and norepinephrine did not change over time, while sE-selectin was significantly lower at 1-h PE (10.25±1.07 ng/mL, p=0.04) than at baseline (12.22±1.39 ng/mL). Cortisol and sICAM-1 were negatively related at 1-h PE following lower-intensity exercise (r2=0.34, p=0.02), whereas cortisol and sVCAM-1 were positively related at IPE following higher-intensity exercise (r2=0.36, p=0.02).Conclusion: Regardless of intensity, an acute bout of aerobic exercise may lower sE-selectin in sedentary obese men. Responses of cortisol are dependent on exercise intensity, and cortisol may be a key stress hormone playing a major role in regulating sICAM-1 and sVCAM-1. Keywords: vascular inflammation, ICAM-1, VACM-1, E-selectin, stress hormones, exercise intensityhttps://www.dovepress.com/exercise-induced-changes-in-stress-hormones-and-cell-adhesion-molecule-peer-reviewed-article-JIRVascular inflammationICAM-1VACM-1E-selectinStress hormonesExercise intensity |
| spellingShingle | Park J Willoughby DS Song JJ Leutholtz BC Koh Y Exercise-induced changes in stress hormones and cell adhesion molecules in obese men Journal of Inflammation Research Vascular inflammation ICAM-1 VACM-1 E-selectin Stress hormones Exercise intensity |
| title | Exercise-induced changes in stress hormones and cell adhesion molecules in obese men |
| title_full | Exercise-induced changes in stress hormones and cell adhesion molecules in obese men |
| title_fullStr | Exercise-induced changes in stress hormones and cell adhesion molecules in obese men |
| title_full_unstemmed | Exercise-induced changes in stress hormones and cell adhesion molecules in obese men |
| title_short | Exercise-induced changes in stress hormones and cell adhesion molecules in obese men |
| title_sort | exercise induced changes in stress hormones and cell adhesion molecules in obese men |
| topic | Vascular inflammation ICAM-1 VACM-1 E-selectin Stress hormones Exercise intensity |
| url | https://www.dovepress.com/exercise-induced-changes-in-stress-hormones-and-cell-adhesion-molecule-peer-reviewed-article-JIR |
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