Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM)
Data from the Polish Registry of Congenital Malformations (PRCM) suggest that the prevalence of limb reduction defects (LRDs) in some Polish regions is significantly higher in comparison to that reported in the European Surveillance of Congenital Anomalies (EUROCAT) registry, but specific risk facto...
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MDPI AG
2021-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/2/138 |
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| author | Anna Materna-Kiryluk Katarzyna Wisniewska Barbara Wieckowska Jolanta Wierzba Anna Jazdzewska Beata Jaroszewska-Swiatek Kinga Skotnicka Anna Latos-Bielenska |
| author_facet | Anna Materna-Kiryluk Katarzyna Wisniewska Barbara Wieckowska Jolanta Wierzba Anna Jazdzewska Beata Jaroszewska-Swiatek Kinga Skotnicka Anna Latos-Bielenska |
| author_sort | Anna Materna-Kiryluk |
| collection | DOAJ |
| description | Data from the Polish Registry of Congenital Malformations (PRCM) suggest that the prevalence of limb reduction defects (LRDs) in some Polish regions is significantly higher in comparison to that reported in the European Surveillance of Congenital Anomalies (EUROCAT) registry, but specific risk factors are still unknown. The objectives of this study were two-fold: to detect risk factors linked to isolated LRDs among Polish natives and to search for geospatial clusters of isolated LRDs to identify high-risk areas across the country. Among the 2,939,001 births accounted for in the PRCM, we determined that there were 852 children with distinct LRDs. Our data demonstrate that lower birth weight, prematurity, and maternal smoking history are strongly associated with isolated LRDs. Furthermore, our investigation pointed to various additional risk factors for isolated LRDs, including paternal education, gestational hypertension, upper respiratory tract infections, and exposure to anti-inflammatory drugs in the first trimester of pregnancy. We did not recognize statistically significant spatial or spatiotemporal clusters over the area of Poland using Kulldorff’s scan. Our study strengthens the hypothesis that maternal factors have an integral role in the etiology of isolated LRDs. |
| first_indexed | 2024-03-09T00:56:11Z |
| format | Article |
| id | doaj.art-0441a766e66742cb82b031e4e873407f |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T00:56:11Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-0441a766e66742cb82b031e4e873407f2023-12-11T16:52:34ZengMDPI AGChildren2227-90672021-02-018213810.3390/children8020138Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM)Anna Materna-Kiryluk0Katarzyna Wisniewska1Barbara Wieckowska2Jolanta Wierzba3Anna Jazdzewska4Beata Jaroszewska-Swiatek5Kinga Skotnicka6Anna Latos-Bielenska7Polish Registry of Congenital Malformations, Chair and Department of Medical Genetics, University of Medical Sciences, 61-701 Poznan, PolandEpidemiology Unit, Department of Preventive Medicine Poznan, University of Medical Sciences, 61-701 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Internal and Pediatric Nursing, Medical University of Gdansk, 80-952 Gdansk, PolandSurgery and Burn Treatment Unit, Specialist Mother and Child Healthcare Centre in Poznan, 61-825 Poznan, PolandDepartment of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Children’s Hospital in Olsztyn, 10-561 Olsztyn, PolandPolish Registry of Congenital Malformations, Chair and Department of Medical Genetics, University of Medical Sciences, 61-701 Poznan, PolandPolish Registry of Congenital Malformations, Chair and Department of Medical Genetics, University of Medical Sciences, 61-701 Poznan, PolandData from the Polish Registry of Congenital Malformations (PRCM) suggest that the prevalence of limb reduction defects (LRDs) in some Polish regions is significantly higher in comparison to that reported in the European Surveillance of Congenital Anomalies (EUROCAT) registry, but specific risk factors are still unknown. The objectives of this study were two-fold: to detect risk factors linked to isolated LRDs among Polish natives and to search for geospatial clusters of isolated LRDs to identify high-risk areas across the country. Among the 2,939,001 births accounted for in the PRCM, we determined that there were 852 children with distinct LRDs. Our data demonstrate that lower birth weight, prematurity, and maternal smoking history are strongly associated with isolated LRDs. Furthermore, our investigation pointed to various additional risk factors for isolated LRDs, including paternal education, gestational hypertension, upper respiratory tract infections, and exposure to anti-inflammatory drugs in the first trimester of pregnancy. We did not recognize statistically significant spatial or spatiotemporal clusters over the area of Poland using Kulldorff’s scan. Our study strengthens the hypothesis that maternal factors have an integral role in the etiology of isolated LRDs.https://www.mdpi.com/2227-9067/8/2/138congenital abnormalitieslimb deformitiescongenitalrisk factors |
| spellingShingle | Anna Materna-Kiryluk Katarzyna Wisniewska Barbara Wieckowska Jolanta Wierzba Anna Jazdzewska Beata Jaroszewska-Swiatek Kinga Skotnicka Anna Latos-Bielenska Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) Children congenital abnormalities limb deformities congenital risk factors |
| title | Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) |
| title_full | Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) |
| title_fullStr | Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) |
| title_full_unstemmed | Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) |
| title_short | Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM) |
| title_sort | maternal risk factors associated with limb reduction defects data from the polish registry of congenital malformations prcm |
| topic | congenital abnormalities limb deformities congenital risk factors |
| url | https://www.mdpi.com/2227-9067/8/2/138 |
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