Implications of divergence of methionine adenosyltransferase in archaea

Implications of divergence of methionine adenosyltransferase in archaea

Methionine adenosyltransferase (MAT) catalyzes the biosynthesis of S‐adenosyl methionine from l‐methionine and ATP. MAT enzymes are ancient, believed to share a common ancestor, and are highly conserved in all three domains of life. However, the sequences of archaeal MATs show considerable divergenc...

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Bibliographic Details
Main Authors: Bhanu Pratap Singh Chouhan, Madhuri Gade, Desirae Martinez, Saacnicteh Toledo‐Patino, Paola Laurino
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:FEBS Open Bio
Subjects:
ancestral sequence reconstruction
catalytic interface
divergence
enzyme evolution
methionine adenosyltransferase
Online Access:https://doi.org/10.1002/2211-5463.13312

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