Inflammasome: A Double-Edged Sword in Liver Diseases
Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interle...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-09-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/full |
_version_ | 1811229272611749888 |
---|---|
author | Jingyun Luan Dianwen Ju |
author_facet | Jingyun Luan Dianwen Ju |
author_sort | Jingyun Luan |
collection | DOAJ |
description | Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases. |
first_indexed | 2024-04-12T10:11:48Z |
format | Article |
id | doaj.art-04438a8e53a84a9993767077fa08730b |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-12T10:11:48Z |
publishDate | 2018-09-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-04438a8e53a84a9993767077fa08730b2022-12-22T03:37:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02201411391Inflammasome: A Double-Edged Sword in Liver DiseasesJingyun LuanDianwen JuInflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/fullinflammasomeliverpyroptosisinnate immuneadaptive immunemetabolism |
spellingShingle | Jingyun Luan Dianwen Ju Inflammasome: A Double-Edged Sword in Liver Diseases Frontiers in Immunology inflammasome liver pyroptosis innate immune adaptive immune metabolism |
title | Inflammasome: A Double-Edged Sword in Liver Diseases |
title_full | Inflammasome: A Double-Edged Sword in Liver Diseases |
title_fullStr | Inflammasome: A Double-Edged Sword in Liver Diseases |
title_full_unstemmed | Inflammasome: A Double-Edged Sword in Liver Diseases |
title_short | Inflammasome: A Double-Edged Sword in Liver Diseases |
title_sort | inflammasome a double edged sword in liver diseases |
topic | inflammasome liver pyroptosis innate immune adaptive immune metabolism |
url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/full |
work_keys_str_mv | AT jingyunluan inflammasomeadoubleedgedswordinliverdiseases AT dianwenju inflammasomeadoubleedgedswordinliverdiseases |