Inflammasome: A Double-Edged Sword in Liver Diseases

Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interle...

Full description

Bibliographic Details
Main Authors: Jingyun Luan, Dianwen Ju
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/full
_version_ 1811229272611749888
author Jingyun Luan
Dianwen Ju
author_facet Jingyun Luan
Dianwen Ju
author_sort Jingyun Luan
collection DOAJ
description Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.
first_indexed 2024-04-12T10:11:48Z
format Article
id doaj.art-04438a8e53a84a9993767077fa08730b
institution Directory Open Access Journal
issn 1664-3224
language English
last_indexed 2024-04-12T10:11:48Z
publishDate 2018-09-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Immunology
spelling doaj.art-04438a8e53a84a9993767077fa08730b2022-12-22T03:37:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02201411391Inflammasome: A Double-Edged Sword in Liver DiseasesJingyun LuanDianwen JuInflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/fullinflammasomeliverpyroptosisinnate immuneadaptive immunemetabolism
spellingShingle Jingyun Luan
Dianwen Ju
Inflammasome: A Double-Edged Sword in Liver Diseases
Frontiers in Immunology
inflammasome
liver
pyroptosis
innate immune
adaptive immune
metabolism
title Inflammasome: A Double-Edged Sword in Liver Diseases
title_full Inflammasome: A Double-Edged Sword in Liver Diseases
title_fullStr Inflammasome: A Double-Edged Sword in Liver Diseases
title_full_unstemmed Inflammasome: A Double-Edged Sword in Liver Diseases
title_short Inflammasome: A Double-Edged Sword in Liver Diseases
title_sort inflammasome a double edged sword in liver diseases
topic inflammasome
liver
pyroptosis
innate immune
adaptive immune
metabolism
url https://www.frontiersin.org/article/10.3389/fimmu.2018.02201/full
work_keys_str_mv AT jingyunluan inflammasomeadoubleedgedswordinliverdiseases
AT dianwenju inflammasomeadoubleedgedswordinliverdiseases