Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Abstract Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TBI. However, the vascular...

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Bibliographic Details
Main Authors: Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
Traumatic brain injury
Alzheimer’s disease
Microvascular injury
Blood–brain barrier
β-amyloid
Online Access:https://doi.org/10.1186/s40478-021-01178-7

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