Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury
Abstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cockta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2017-02-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-017-0373-y |
| _version_ | 1797727322756874240 |
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| author | Yuewen Tang Lin Cheng |
| author_facet | Yuewen Tang Lin Cheng |
| author_sort | Yuewen Tang |
| collection | DOAJ |
| description | Abstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that the drug cocktails which promoted cell reprogramming in vitro improved liver regeneration and hepatic function in vivo after acute injuries. The underlying mechanism could be that expression of pluripotent genes activated after injury is further upregulated by drug cocktails. Thus our study offers proof-of-concept evidence that cocktail of clinical compounds improving cell reprogramming favors tissue recovery after acute damages, which is an attractive strategy for regenerative purpose. |
| first_indexed | 2024-03-12T10:59:09Z |
| format | Article |
| id | doaj.art-0446105172104d04a76e1c44f27b617c |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T10:59:09Z |
| publishDate | 2017-02-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-0446105172104d04a76e1c44f27b617c2023-09-02T05:59:34ZengOxford University PressProtein & Cell1674-800X1674-80182017-02-018427328310.1007/s13238-017-0373-yCocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injuryYuewen Tang0Lin Cheng1State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of MedicineAbstract Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that the drug cocktails which promoted cell reprogramming in vitro improved liver regeneration and hepatic function in vivo after acute injuries. The underlying mechanism could be that expression of pluripotent genes activated after injury is further upregulated by drug cocktails. Thus our study offers proof-of-concept evidence that cocktail of clinical compounds improving cell reprogramming favors tissue recovery after acute damages, which is an attractive strategy for regenerative purpose.http://link.springer.com/article/10.1007/s13238-017-0373-ycell reprogrammingchemical compoundsliver regeneration |
| spellingShingle | Yuewen Tang Lin Cheng Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury Protein & Cell cell reprogramming chemical compounds liver regeneration |
| title | Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| title_full | Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| title_fullStr | Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| title_full_unstemmed | Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| title_short | Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| title_sort | cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |
| topic | cell reprogramming chemical compounds liver regeneration |
| url | http://link.springer.com/article/10.1007/s13238-017-0373-y |
| work_keys_str_mv | AT yuewentang cocktailofchemicalcompoundsrobustlypromotingcellreprogrammingprotectsliveragainstacuteinjury AT lincheng cocktailofchemicalcompoundsrobustlypromotingcellreprogrammingprotectsliveragainstacuteinjury |