CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however, their effectiveness against solid tumors remains a hurdle. Recently, CD44v6-directed CAR-T cells demonstrated efficacy in controlling tumor gr...

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Bibliographic Details
Main Authors: Ioana Sonya Ciulean, Joe Fischer, Andrea Quaiser, Christoph Bach, Hinrich Abken, Uta Sandy Tretbar, Stephan Fricke, Ulrike Koehl, Dominik Schmiedel, Thomas Grunwald
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
CAR-NK cells
head and neck cancer
CD44v6
NK cells
solid tumor
immune cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1290488/full

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