Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in v...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-05-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00289/full |
| _version_ | 1818944385137508352 |
|---|---|
| author | Jialiang Gao Guang Chen Guang Chen Haoqiang He Haoqiang He Chao Liu Chao Liu Xingjiang Xiong Jun Li Jie Wang |
| author_facet | Jialiang Gao Guang Chen Guang Chen Haoqiang He Haoqiang He Chao Liu Chao Liu Xingjiang Xiong Jun Li Jie Wang |
| author_sort | Jialiang Gao |
| collection | DOAJ |
| description | Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications. |
| first_indexed | 2024-12-20T07:42:23Z |
| format | Article |
| id | doaj.art-044c3cb8aa52485294ef8e3155d079c3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T07:42:23Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-044c3cb8aa52485294ef8e3155d079c32022-12-21T19:48:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-05-01810.3389/fphar.2017.00289253474Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A ReviewJialiang Gao0Guang Chen1Guang Chen2Haoqiang He3Haoqiang He4Chao Liu5Chao Liu6Xingjiang Xiong7Jun Li8Jie Wang9Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaGraduate School, Beijing University of Chinese MedicineBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaGraduate School, Beijing University of Chinese MedicineBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaGraduate School, Beijing University of Chinese MedicineBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing, ChinaBreviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications.http://journal.frontiersin.org/article/10.3389/fphar.2017.00289/fullbreviscapineChinese medicineethnopharmacologyherbal medicineherbal active compounds |
| spellingShingle | Jialiang Gao Guang Chen Guang Chen Haoqiang He Haoqiang He Chao Liu Chao Liu Xingjiang Xiong Jun Li Jie Wang Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review Frontiers in Pharmacology breviscapine Chinese medicine ethnopharmacology herbal medicine herbal active compounds |
| title | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
| title_full | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
| title_fullStr | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
| title_full_unstemmed | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
| title_short | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
| title_sort | therapeutic effects of breviscapine in cardiovascular diseases a review |
| topic | breviscapine Chinese medicine ethnopharmacology herbal medicine herbal active compounds |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00289/full |
| work_keys_str_mv | AT jialianggao therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT guangchen therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT guangchen therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT haoqianghe therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT haoqianghe therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT chaoliu therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT chaoliu therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT xingjiangxiong therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT junli therapeuticeffectsofbreviscapineincardiovasculardiseasesareview AT jiewang therapeuticeffectsofbreviscapineincardiovasculardiseasesareview |