Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity
Abstract Objective To compare post-treatment recurrence between ranibizumab injection and laser photocoagulation (LP) for type 1 retinopathy of prematurity (ROP), and explore the associated risk factors. Methods The clinical data of ROP infants treated with LP or ranibizumab in a NICU of China from...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-02886-5 |
| _version_ | 1797850141039788032 |
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| author | Jing-Ke Cao Tao Han Hong-Yi Tang Sheng Zhang Zong-Hua Wang Zhi-Chun Feng Qiu-Ping Li |
| author_facet | Jing-Ke Cao Tao Han Hong-Yi Tang Sheng Zhang Zong-Hua Wang Zhi-Chun Feng Qiu-Ping Li |
| author_sort | Jing-Ke Cao |
| collection | DOAJ |
| description | Abstract Objective To compare post-treatment recurrence between ranibizumab injection and laser photocoagulation (LP) for type 1 retinopathy of prematurity (ROP), and explore the associated risk factors. Methods The clinical data of ROP infants treated with LP or ranibizumab in a NICU of China from October 2007 to November 2021 were retrospectively analyzed and compared, such as general condition, degree of ROP, therapeutic effectiveness and post-treatment recurrence. The dependent variable was recurrence after ROP treatment. Univariate and regression analysis of risk factors was performed. Results Of the 298 ROP infants (556 eyes), 58% of the eyes were treated with LP and the other 42% with ranibizumab. There was no significant difference in gestational age at birth, birth weight, sex, delivery mode, prenatal corticosteroids, ROP diagnosed before admission or after admission, and the duration of oxygen therapy between the two groups. However, the ratio of type 1 ROP and aggressive retinopathy of prematurity (A-ROP) in ranibizumab group was higher than that in LP group. The number of treatments, recurrence rate and recurrence interval in ranibizumab group were higher than those in LP group. However, there was no difference in the recurrence rate between the two groups after stratified analysis by the lesion area and the presence or absence of A-ROP. There was no significant difference in the final lesion regression between the two groups. Regression analysis showed that plus disease and ROP located in zone I were independent risk factors for post-treatment recurrence. Conclusion There is no significant difference in the recurrence rate of ROP between ranibizumab injection and LP, and recurrence is mainly related to the severity of ROP. In half of our patients treated with A-ROP recurrences occur. |
| first_indexed | 2024-04-09T18:55:34Z |
| format | Article |
| id | doaj.art-044d89bbb7034046ad56b104e4fc5feb |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-09T18:55:34Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-044d89bbb7034046ad56b104e4fc5feb2023-04-09T11:11:08ZengBMCBMC Ophthalmology1471-24152023-04-012311810.1186/s12886-023-02886-5Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurityJing-Ke Cao0Tao Han1Hong-Yi Tang2Sheng Zhang3Zong-Hua Wang4Zhi-Chun Feng5Qiu-Ping Li6The Second School of Clinical Medicine, Southern Medical UniversityDepartment of Neonatology, Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General HospitalThe Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityDepartment of Neonatology, Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General HospitalDepartment of Ophthalmology, the Seventh Medical Center of Chinese PLA General HospitalDepartment of Neonatology, Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General HospitalThe Second School of Clinical Medicine, Southern Medical UniversityAbstract Objective To compare post-treatment recurrence between ranibizumab injection and laser photocoagulation (LP) for type 1 retinopathy of prematurity (ROP), and explore the associated risk factors. Methods The clinical data of ROP infants treated with LP or ranibizumab in a NICU of China from October 2007 to November 2021 were retrospectively analyzed and compared, such as general condition, degree of ROP, therapeutic effectiveness and post-treatment recurrence. The dependent variable was recurrence after ROP treatment. Univariate and regression analysis of risk factors was performed. Results Of the 298 ROP infants (556 eyes), 58% of the eyes were treated with LP and the other 42% with ranibizumab. There was no significant difference in gestational age at birth, birth weight, sex, delivery mode, prenatal corticosteroids, ROP diagnosed before admission or after admission, and the duration of oxygen therapy between the two groups. However, the ratio of type 1 ROP and aggressive retinopathy of prematurity (A-ROP) in ranibizumab group was higher than that in LP group. The number of treatments, recurrence rate and recurrence interval in ranibizumab group were higher than those in LP group. However, there was no difference in the recurrence rate between the two groups after stratified analysis by the lesion area and the presence or absence of A-ROP. There was no significant difference in the final lesion regression between the two groups. Regression analysis showed that plus disease and ROP located in zone I were independent risk factors for post-treatment recurrence. Conclusion There is no significant difference in the recurrence rate of ROP between ranibizumab injection and LP, and recurrence is mainly related to the severity of ROP. In half of our patients treated with A-ROP recurrences occur.https://doi.org/10.1186/s12886-023-02886-5RanibizumabLaser photocoagulationRetinopathy of prematurityTreatment |
| spellingShingle | Jing-Ke Cao Tao Han Hong-Yi Tang Sheng Zhang Zong-Hua Wang Zhi-Chun Feng Qiu-Ping Li Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity BMC Ophthalmology Ranibizumab Laser photocoagulation Retinopathy of prematurity Treatment |
| title | Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| title_full | Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| title_fullStr | Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| title_full_unstemmed | Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| title_short | Comparison of post-treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| title_sort | comparison of post treatment recurrence between ranibizumab injection and laser photocoagulation for type 1 retinopathy of prematurity |
| topic | Ranibizumab Laser photocoagulation Retinopathy of prematurity Treatment |
| url | https://doi.org/10.1186/s12886-023-02886-5 |
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