Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice
The use of ordered mesoporous matrices, and in particular carbon-based mesoporous nanoparticles has shown great potential towards enhancing the bioavailability of orally administered drugs. Nevertheless, elucidation of the in vivo absorption, distribution, and excretion of such carriers is essential...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/11/12/3260 |
| _version_ | 1797502018905964544 |
|---|---|
| author | Maria Mamai Dimitra Giasafaki Evangelia-Alexandra Salvanou Georgia Charalambopoulou Theodore Steriotis Penelope Bouziotis |
| author_facet | Maria Mamai Dimitra Giasafaki Evangelia-Alexandra Salvanou Georgia Charalambopoulou Theodore Steriotis Penelope Bouziotis |
| author_sort | Maria Mamai |
| collection | DOAJ |
| description | The use of ordered mesoporous matrices, and in particular carbon-based mesoporous nanoparticles has shown great potential towards enhancing the bioavailability of orally administered drugs. Nevertheless, elucidation of the in vivo absorption, distribution, and excretion of such carriers is essential for understanding their behaviour, and radiolabelling provides a very useful way to track their occurrence inside the body. In this work, uniform spherical CMK-1-type ordered mesoporous carbon nanoparticles have been radiolabelled with Technetium-99m (<sup>99m</sup>Tc) and traced after oral administration to mice. Ex vivo biodistribution studies showed that the radiolabelled nanoparticles accumulated almost exclusively in the gastrointestinal tract; complete elimination of the radiotracer was observed within 24 h after administration, with practically no uptake into other main organs. These findings along with the results from in vitro stability studies indicate that the spherical carbon nanoparticles examined could be safely used as drug carriers with minimal side effects, but also support the great value of radiolabelling methods for monitoring the particles’ behaviour in vivo. |
| first_indexed | 2024-03-10T03:26:56Z |
| format | Article |
| id | doaj.art-044f8e2a215c4de1adbdd3c20720e175 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:26:56Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-044f8e2a215c4de1adbdd3c20720e1752023-11-23T09:50:10ZengMDPI AGNanomaterials2079-49912021-11-011112326010.3390/nano11123260Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to MiceMaria Mamai0Dimitra Giasafaki1Evangelia-Alexandra Salvanou2Georgia Charalambopoulou3Theodore Steriotis4Penelope Bouziotis5Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceInstitute of Nanoscience & Nanotechnology, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceInstitute of Nuclear & Radiological Sciences and Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceInstitute of Nuclear & Radiological Sciences and Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceInstitute of Nanoscience & Nanotechnology, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceInstitute of Nuclear & Radiological Sciences and Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceThe use of ordered mesoporous matrices, and in particular carbon-based mesoporous nanoparticles has shown great potential towards enhancing the bioavailability of orally administered drugs. Nevertheless, elucidation of the in vivo absorption, distribution, and excretion of such carriers is essential for understanding their behaviour, and radiolabelling provides a very useful way to track their occurrence inside the body. In this work, uniform spherical CMK-1-type ordered mesoporous carbon nanoparticles have been radiolabelled with Technetium-99m (<sup>99m</sup>Tc) and traced after oral administration to mice. Ex vivo biodistribution studies showed that the radiolabelled nanoparticles accumulated almost exclusively in the gastrointestinal tract; complete elimination of the radiotracer was observed within 24 h after administration, with practically no uptake into other main organs. These findings along with the results from in vitro stability studies indicate that the spherical carbon nanoparticles examined could be safely used as drug carriers with minimal side effects, but also support the great value of radiolabelling methods for monitoring the particles’ behaviour in vivo.https://www.mdpi.com/2079-4991/11/12/3260CMK-1mesoporous carbon nanoparticlesradiolabellingTechnetium-99moral administrationbiodegradation |
| spellingShingle | Maria Mamai Dimitra Giasafaki Evangelia-Alexandra Salvanou Georgia Charalambopoulou Theodore Steriotis Penelope Bouziotis Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice Nanomaterials CMK-1 mesoporous carbon nanoparticles radiolabelling Technetium-99m oral administration biodegradation |
| title | Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice |
| title_full | Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice |
| title_fullStr | Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice |
| title_full_unstemmed | Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice |
| title_short | Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice |
| title_sort | biodistribution of mesoporous carbon nanoparticles via technetium 99m radiolabelling after oral administration to mice |
| topic | CMK-1 mesoporous carbon nanoparticles radiolabelling Technetium-99m oral administration biodegradation |
| url | https://www.mdpi.com/2079-4991/11/12/3260 |
| work_keys_str_mv | AT mariamamai biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice AT dimitragiasafaki biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice AT evangeliaalexandrasalvanou biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice AT georgiacharalambopoulou biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice AT theodoresteriotis biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice AT penelopebouziotis biodistributionofmesoporouscarbonnanoparticlesviatechnetium99mradiolabellingafteroraladministrationtomice |