Feasibility of Using Gluconolactone, Trehalose and Hydroxy-Propyl Gamma Cyclodextrin to Enhance Bendroflumethiazide Dissolution Using Lyophilisation and Physical Mixing Techniques

Feasibility of Using Gluconolactone, Trehalose and Hydroxy-Propyl Gamma Cyclodextrin to Enhance Bendroflumethiazide Dissolution Using Lyophilisation and Physical Mixing Techniques

Purpose: Hydrophobic drugs are facing a major challenge in dissolution rate enhancement and solubility in aqueous solutions; therefore, a variety of methods have been used to improve dissolution rate and/or solubility of bendroflumethiazide as a model hydrophobic drug. Methods: In this study, two ma...

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Bibliographic Details
Main Authors: Ashraf Saleh, Kenneth McGarry, Cheng Shu Chaw, Amal Ali Elkordy
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Pharmaceutics
Subjects:
bendroflumethiazide
hydrophobic drug
lyophilisation
gluconolactone
hydroxyl propyl γ-cyclodextrin
trehalose
dissolution rate
Online Access:http://www.mdpi.com/1999-4923/10/1/22

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