Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects
Major depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in mos...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/8/821 |
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| author | Miguel A. Alvarez-Mon Miguel A. Ortega Cielo García-Montero Oscar Fraile-Martinez Jorge Monserrat Guillermo Lahera Fernando Mora Alberto Rodriguez-Quiroga Sonia Fernandez-Rojo Javier Quintero Melchor Alvarez-Mon |
| author_facet | Miguel A. Alvarez-Mon Miguel A. Ortega Cielo García-Montero Oscar Fraile-Martinez Jorge Monserrat Guillermo Lahera Fernando Mora Alberto Rodriguez-Quiroga Sonia Fernandez-Rojo Javier Quintero Melchor Alvarez-Mon |
| author_sort | Miguel A. Alvarez-Mon |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in most severe cases. However, an important percentage of depressed patients fail to respond to the use of conventional therapies. This has created the urgency of finding novel approaches to help in the clinical management of those individuals. Nutraceuticals are natural compounds contained in food with proven benefits either in health promotion or disease prevention and therapy. A growing interest and economical sources are being placed in the development and understanding of multiple nutraceutical products. Here, we summarize some of the most relevant nutraceutical agents evaluated in preclinical and clinical models of depression. In addition, we will also explore less frequent but interest nutraceutical products which are starting to be tested, also evaluating future roads to cover in order to maximize the benefits of nutraceuticals in MDD. |
| first_indexed | 2024-03-10T08:28:54Z |
| format | Article |
| id | doaj.art-0451fde19e7842638b0b148ec502ca96 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T08:28:54Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0451fde19e7842638b0b148ec502ca962023-11-22T09:12:20ZengMDPI AGPharmaceuticals1424-82472021-08-0114882110.3390/ph14080821Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future ProspectsMiguel A. Alvarez-Mon0Miguel A. Ortega1Cielo García-Montero2Oscar Fraile-Martinez3Jorge Monserrat4Guillermo Lahera5Fernando Mora6Alberto Rodriguez-Quiroga7Sonia Fernandez-Rojo8Javier Quintero9Melchor Alvarez-Mon10Department of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainDepartment of Medicine and Medical Specialities, University of Alcala, 28801 Alcala de Henares, SpainMajor depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in most severe cases. However, an important percentage of depressed patients fail to respond to the use of conventional therapies. This has created the urgency of finding novel approaches to help in the clinical management of those individuals. Nutraceuticals are natural compounds contained in food with proven benefits either in health promotion or disease prevention and therapy. A growing interest and economical sources are being placed in the development and understanding of multiple nutraceutical products. Here, we summarize some of the most relevant nutraceutical agents evaluated in preclinical and clinical models of depression. In addition, we will also explore less frequent but interest nutraceutical products which are starting to be tested, also evaluating future roads to cover in order to maximize the benefits of nutraceuticals in MDD.https://www.mdpi.com/1424-8247/14/8/821major depressive disorder (MDD)nutraceuticalsomega 3 fatty acidsS-Adenosyl-methionine (SAMe)vitamin Dmethylfolate |
| spellingShingle | Miguel A. Alvarez-Mon Miguel A. Ortega Cielo García-Montero Oscar Fraile-Martinez Jorge Monserrat Guillermo Lahera Fernando Mora Alberto Rodriguez-Quiroga Sonia Fernandez-Rojo Javier Quintero Melchor Alvarez-Mon Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects Pharmaceuticals major depressive disorder (MDD) nutraceuticals omega 3 fatty acids S-Adenosyl-methionine (SAMe) vitamin D methylfolate |
| title | Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects |
| title_full | Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects |
| title_fullStr | Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects |
| title_full_unstemmed | Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects |
| title_short | Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects |
| title_sort | exploring the role of nutraceuticals in major depressive disorder mdd rationale state of the art and future prospects |
| topic | major depressive disorder (MDD) nutraceuticals omega 3 fatty acids S-Adenosyl-methionine (SAMe) vitamin D methylfolate |
| url | https://www.mdpi.com/1424-8247/14/8/821 |
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