Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis
BackgroundSerum pepsinogens are serological biomarkers of gastric atrophy, and the latter is a risk factor for esophageal squamous cell carcinoma (ESCC). However, the association of serum pepsinogens with ESCC risk remains unclear. This systematic review and meta-analysis aimed to assess the relatio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.928672/full |
| _version_ | 1818549609802235904 |
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| author | Zhen-Xiao Yang Zhen-Xiao Yang Lu-Bin Yan Peng Xie Peng Hu Wenjing Zhao Yi Lu Xiangbing Xing Xudong Liu |
| author_facet | Zhen-Xiao Yang Zhen-Xiao Yang Lu-Bin Yan Peng Xie Peng Hu Wenjing Zhao Yi Lu Xiangbing Xing Xudong Liu |
| author_sort | Zhen-Xiao Yang |
| collection | DOAJ |
| description | BackgroundSerum pepsinogens are serological biomarkers of gastric atrophy, and the latter is a risk factor for esophageal squamous cell carcinoma (ESCC). However, the association of serum pepsinogens with ESCC risk remains unclear. This systematic review and meta-analysis aimed to assess the relationship between serum pepsinogen I (PGI) and pepsinogen I: pepsinogen II ratio (PGR) and ESCC risk.MethodsPubMed, Embase, and Web of Science were searched for articles on the effect of serum PGI and PGR on ESCC risk, published up to the end of February 2022. Meta-analysis with a random-effect model was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).ResultsFive case–control studies and three prospective studies were included. In comparison with the high categories, the low categories of serum PGI (OR: 1.92, 95% CI: 1.45–2.56) and PGR (OR: 1.70, 95% CI: 1.01–2.85) were associated with an increased risk of ESCC, although a substantial heterogeneity was observed in serum PGR (I2 = 60.2%, P = 0.028) rather than in serum PGI (I2 = 46.4%, P = 0.070). In stratified analysis by study quality, the significant risk effect on ESCC was remained for PGI (OR: 2.05, 95% CI: 1.48–2.84) and PGR (OR: 2.07, 95% CI: 1.17–3.75) when only the studies with high quality were pooled.ConclusionsBased on the available studies, although limited in number, this systematic review along with meta-analysis suggests that low serum PGI and low PGR may be related to an increased risk of ESCC. This present study provides evidence for using serum pepsinogen biomarkers in predicting ESCC. More delicate well-designed cohort studies with high study quality are needed, and dose–response analysis should be performed. |
| first_indexed | 2024-12-12T08:35:35Z |
| format | Article |
| id | doaj.art-04581987c400442e9cc3009668e21656 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T08:35:35Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-04581987c400442e9cc3009668e216562022-12-22T00:30:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.928672928672Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-AnalysisZhen-Xiao Yang0Zhen-Xiao Yang1Lu-Bin Yan2Peng Xie3Peng Hu4Wenjing Zhao5Yi Lu6Xiangbing Xing7Xudong Liu8Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Pediatric Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery, Xi’an Aerospace General Hospital, Xi’an, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, ChinaHealth Effects Institute, Boston, MA, United StatesDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, ChinaBackgroundSerum pepsinogens are serological biomarkers of gastric atrophy, and the latter is a risk factor for esophageal squamous cell carcinoma (ESCC). However, the association of serum pepsinogens with ESCC risk remains unclear. This systematic review and meta-analysis aimed to assess the relationship between serum pepsinogen I (PGI) and pepsinogen I: pepsinogen II ratio (PGR) and ESCC risk.MethodsPubMed, Embase, and Web of Science were searched for articles on the effect of serum PGI and PGR on ESCC risk, published up to the end of February 2022. Meta-analysis with a random-effect model was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).ResultsFive case–control studies and three prospective studies were included. In comparison with the high categories, the low categories of serum PGI (OR: 1.92, 95% CI: 1.45–2.56) and PGR (OR: 1.70, 95% CI: 1.01–2.85) were associated with an increased risk of ESCC, although a substantial heterogeneity was observed in serum PGR (I2 = 60.2%, P = 0.028) rather than in serum PGI (I2 = 46.4%, P = 0.070). In stratified analysis by study quality, the significant risk effect on ESCC was remained for PGI (OR: 2.05, 95% CI: 1.48–2.84) and PGR (OR: 2.07, 95% CI: 1.17–3.75) when only the studies with high quality were pooled.ConclusionsBased on the available studies, although limited in number, this systematic review along with meta-analysis suggests that low serum PGI and low PGR may be related to an increased risk of ESCC. This present study provides evidence for using serum pepsinogen biomarkers in predicting ESCC. More delicate well-designed cohort studies with high study quality are needed, and dose–response analysis should be performed.https://www.frontiersin.org/articles/10.3389/fonc.2022.928672/fullserum pepsinogensesophageal squamous cell carcinomasystematic reviewmeta-analysis researchetiology |
| spellingShingle | Zhen-Xiao Yang Zhen-Xiao Yang Lu-Bin Yan Peng Xie Peng Hu Wenjing Zhao Yi Lu Xiangbing Xing Xudong Liu Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis Frontiers in Oncology serum pepsinogens esophageal squamous cell carcinoma systematic review meta-analysis research etiology |
| title | Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis |
| title_full | Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis |
| title_short | Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis |
| title_sort | association of serum pepsinogens with esophageal squamous cell carcinoma risk a systematic review and meta analysis |
| topic | serum pepsinogens esophageal squamous cell carcinoma systematic review meta-analysis research etiology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.928672/full |
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