Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities

The snp_blup_rel program computes model reliabilities for genomic breeding values. The program assumes a single trait SNP-BLUP model where the breeding value can include a residual polygenic (RPG) effect. The reliability calculation requires elements of the inverse of the mixed model equations (MME)...

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Main Authors: Hafedh Ben Zaabza, Esa A. Mäntysaari, Ismo Strandén
Format: Article
Language:English
Published: Scientific Agricultural Society of Finland 2020-09-01
Series:Agricultural and Food Science
Online Access:https://journal.fi/afs/article/view/95617
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author Hafedh Ben Zaabza
Esa A. Mäntysaari
Ismo Strandén
author_facet Hafedh Ben Zaabza
Esa A. Mäntysaari
Ismo Strandén
author_sort Hafedh Ben Zaabza
collection DOAJ
description The snp_blup_rel program computes model reliabilities for genomic breeding values. The program assumes a single trait SNP-BLUP model where the breeding value can include a residual polygenic (RPG) effect. The reliability calculation requires elements of the inverse of the mixed model equations (MME). The calculation has three steps: 1) MME calculation, 2) MME coefficient matrix inversion, and 3) reliability computation. When needed, the inverted matrix can be saved after step 2. Step 3 can be used separately to new genotypes which do not contribute information to Step 2. When an RPG effect is included, an approximate method based on Monte Carlo sampling is applied. This reduces the MME matrix size and allows including many genotyped individuals. The program is written in Fortran 90/95, and uses LAPACK subroutines which enable multi-threaded parallel computing. The program is efficient in terms of computing time and memory requirements, and can be used to analyze even large genomic data. Thus, the program can be used in calculating model reliabilities for large national genomic evaluations.
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spelling doaj.art-0459faa36b3c4b16a8bf6725c8b5a9e32022-12-22T00:58:06ZengScientific Agricultural Society of FinlandAgricultural and Food Science1459-60671795-18952020-09-0129410.23986/afsci.95617Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilitiesHafedh Ben Zaabza0Esa A. Mäntysaari1Ismo Strandén2Natural Resources Institute Finland (Luke)Natural Resources Institute Finland (Luke)Natural Resources Institute Finland (Luke)The snp_blup_rel program computes model reliabilities for genomic breeding values. The program assumes a single trait SNP-BLUP model where the breeding value can include a residual polygenic (RPG) effect. The reliability calculation requires elements of the inverse of the mixed model equations (MME). The calculation has three steps: 1) MME calculation, 2) MME coefficient matrix inversion, and 3) reliability computation. When needed, the inverted matrix can be saved after step 2. Step 3 can be used separately to new genotypes which do not contribute information to Step 2. When an RPG effect is included, an approximate method based on Monte Carlo sampling is applied. This reduces the MME matrix size and allows including many genotyped individuals. The program is written in Fortran 90/95, and uses LAPACK subroutines which enable multi-threaded parallel computing. The program is efficient in terms of computing time and memory requirements, and can be used to analyze even large genomic data. Thus, the program can be used in calculating model reliabilities for large national genomic evaluations.https://journal.fi/afs/article/view/95617
spellingShingle Hafedh Ben Zaabza
Esa A. Mäntysaari
Ismo Strandén
Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
Agricultural and Food Science
title Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
title_full Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
title_fullStr Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
title_full_unstemmed Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
title_short Snp_blup_rel: software for calculating individual animal SNP-BLUP model reliabilities
title_sort snp blup rel software for calculating individual animal snp blup model reliabilities
url https://journal.fi/afs/article/view/95617
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