Role of CD68 in tumor immunity and prognosis prediction in pan-cancer
Abstract CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression datasets. The relationship between C...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11503-2 |
| _version_ | 1811253224262336512 |
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| author | Jingwei Zhang Shuwang Li Fangkun Liu Kui Yang |
| author_facet | Jingwei Zhang Shuwang Li Fangkun Liu Kui Yang |
| author_sort | Jingwei Zhang |
| collection | DOAJ |
| description | Abstract CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression datasets. The relationship between CD68 expression and cancer prognosis, immune infiltration, checkpoint markers, and drug response was explored. Upregulated CD68 levels were observed in various cancer types, which were verified through tumor tissue chips using immunohistochemistry. High levels of CD68 in tumor samples correlated with an adverse prognosis in glioblastoma, kidney renal clear cell carcinoma, lower-grade glioma, liver hepatocellular carcinoma, lung squamous cell carcinoma, thyroid carcinoma, and thymoma and a favorable prognosis in kidney chromophobe. The top three negatively enriched Kyoto Encyclopedia of Genes and Genomes terms in the high CD68 subgroup were chemokine signaling pathway, cytokine-cytokine receptor interaction, and cell adhesion molecule cams. The top negatively enriched HALLMARK terms included complement, allograft rejection, and inflammatory response. A series of targeted drugs and small-molecule drugs with promising therapeutic effects were predicted. The clinical prognosis and immune infiltration of high expression levels of CD68 differ across tumor types. Inhibiting CD68-dependent signaling could be a promising therapeutic strategy for immunotherapy in many tumor types. |
| first_indexed | 2024-04-12T16:47:37Z |
| format | Article |
| id | doaj.art-045ab09015cd446a9267ee73a7664a25 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:47:37Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-045ab09015cd446a9267ee73a7664a252022-12-22T03:24:31ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-11503-2Role of CD68 in tumor immunity and prognosis prediction in pan-cancerJingwei Zhang0Shuwang Li1Fangkun Liu2Kui Yang3Department of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityAbstract CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression datasets. The relationship between CD68 expression and cancer prognosis, immune infiltration, checkpoint markers, and drug response was explored. Upregulated CD68 levels were observed in various cancer types, which were verified through tumor tissue chips using immunohistochemistry. High levels of CD68 in tumor samples correlated with an adverse prognosis in glioblastoma, kidney renal clear cell carcinoma, lower-grade glioma, liver hepatocellular carcinoma, lung squamous cell carcinoma, thyroid carcinoma, and thymoma and a favorable prognosis in kidney chromophobe. The top three negatively enriched Kyoto Encyclopedia of Genes and Genomes terms in the high CD68 subgroup were chemokine signaling pathway, cytokine-cytokine receptor interaction, and cell adhesion molecule cams. The top negatively enriched HALLMARK terms included complement, allograft rejection, and inflammatory response. A series of targeted drugs and small-molecule drugs with promising therapeutic effects were predicted. The clinical prognosis and immune infiltration of high expression levels of CD68 differ across tumor types. Inhibiting CD68-dependent signaling could be a promising therapeutic strategy for immunotherapy in many tumor types.https://doi.org/10.1038/s41598-022-11503-2 |
| spellingShingle | Jingwei Zhang Shuwang Li Fangkun Liu Kui Yang Role of CD68 in tumor immunity and prognosis prediction in pan-cancer Scientific Reports |
| title | Role of CD68 in tumor immunity and prognosis prediction in pan-cancer |
| title_full | Role of CD68 in tumor immunity and prognosis prediction in pan-cancer |
| title_fullStr | Role of CD68 in tumor immunity and prognosis prediction in pan-cancer |
| title_full_unstemmed | Role of CD68 in tumor immunity and prognosis prediction in pan-cancer |
| title_short | Role of CD68 in tumor immunity and prognosis prediction in pan-cancer |
| title_sort | role of cd68 in tumor immunity and prognosis prediction in pan cancer |
| url | https://doi.org/10.1038/s41598-022-11503-2 |
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