Dysregulation of Rho GTPases in Human Cancers
Rho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. Dysregulation of Rho GTPase signaling is observed in a broad range of human cancers, and is associated with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/5/1179 |
| _version_ | 1797568649757720576 |
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| author | Haiyoung Jung Suk Ran Yoon Jeewon Lim Hee Jun Cho Hee Gu Lee |
| author_facet | Haiyoung Jung Suk Ran Yoon Jeewon Lim Hee Jun Cho Hee Gu Lee |
| author_sort | Haiyoung Jung |
| collection | DOAJ |
| description | Rho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. Dysregulation of Rho GTPase signaling is observed in a broad range of human cancers, and is associated with cancer development and malignant phenotypes, including metastasis and chemoresistance. Rho GTPase activity is precisely controlled by guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. Recent evidence demonstrates that it is also regulated by post-translational modifications, such as phosphorylation, ubiquitination, and sumoylation. Here, we review the current knowledge on the role of Rho GTPases, and the precise mechanisms controlling their activity in the regulation of cancer progression. In addition, we discuss targeting strategies for the development of new drugs to improve cancer therapy. |
| first_indexed | 2024-03-10T19:59:00Z |
| format | Article |
| id | doaj.art-045cca2aa6234edb898a4b575a76b19a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:59:00Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-045cca2aa6234edb898a4b575a76b19a2023-11-19T23:40:18ZengMDPI AGCancers2072-66942020-05-01125117910.3390/cancers12051179Dysregulation of Rho GTPases in Human CancersHaiyoung Jung0Suk Ran Yoon1Jeewon Lim2Hee Jun Cho3Hee Gu Lee4Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaRho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. Dysregulation of Rho GTPase signaling is observed in a broad range of human cancers, and is associated with cancer development and malignant phenotypes, including metastasis and chemoresistance. Rho GTPase activity is precisely controlled by guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. Recent evidence demonstrates that it is also regulated by post-translational modifications, such as phosphorylation, ubiquitination, and sumoylation. Here, we review the current knowledge on the role of Rho GTPases, and the precise mechanisms controlling their activity in the regulation of cancer progression. In addition, we discuss targeting strategies for the development of new drugs to improve cancer therapy.https://www.mdpi.com/2072-6694/12/5/1179Rho GTPasescancermigrationmetastasischemoresistance |
| spellingShingle | Haiyoung Jung Suk Ran Yoon Jeewon Lim Hee Jun Cho Hee Gu Lee Dysregulation of Rho GTPases in Human Cancers Cancers Rho GTPases cancer migration metastasis chemoresistance |
| title | Dysregulation of Rho GTPases in Human Cancers |
| title_full | Dysregulation of Rho GTPases in Human Cancers |
| title_fullStr | Dysregulation of Rho GTPases in Human Cancers |
| title_full_unstemmed | Dysregulation of Rho GTPases in Human Cancers |
| title_short | Dysregulation of Rho GTPases in Human Cancers |
| title_sort | dysregulation of rho gtpases in human cancers |
| topic | Rho GTPases cancer migration metastasis chemoresistance |
| url | https://www.mdpi.com/2072-6694/12/5/1179 |
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