Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion
Neuronal physiology depends on a neuron’s ion channel composition and unique morphology. Variable ion channel compositions can produce similar neuronal physiologies across animals. Less is known regarding the morphological precision required to produce reliable neuronal physiology. Theoretical studi...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-02-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/22352 |
_version_ | 1811227961757532160 |
---|---|
author | Adriane G Otopalik Marie L Goeritz Alexander C Sutton Ted Brookings Cosmo Guerini Eve Marder |
author_facet | Adriane G Otopalik Marie L Goeritz Alexander C Sutton Ted Brookings Cosmo Guerini Eve Marder |
author_sort | Adriane G Otopalik |
collection | DOAJ |
description | Neuronal physiology depends on a neuron’s ion channel composition and unique morphology. Variable ion channel compositions can produce similar neuronal physiologies across animals. Less is known regarding the morphological precision required to produce reliable neuronal physiology. Theoretical studies suggest that moraphology is tightly tuned to minimize wiring and conduction delay of synaptic events. We utilize high-resolution confocal microscopy and custom computational tools to characterize the morphologies of four neuron types in the stomatogastric ganglion (STG) of the crab Cancer borealis. Macroscopic branching patterns and fine cable properties are variable within and across neuron types. We compare these neuronal structures to synthetic minimal spanning neurite trees constrained by a wiring cost equation and find that STG neurons do not adhere to prevailing hypotheses regarding wiring optimization principles. In this highly modulated and oscillating circuit, neuronal structures appear to be governed by a space-filling mechanism that outweighs the cost of inefficient wiring. |
first_indexed | 2024-04-12T09:50:31Z |
format | Article |
id | doaj.art-045d17baa315463dbc9a1b7ff0824838 |
institution | Directory Open Access Journal |
issn | 2050-084X |
language | English |
last_indexed | 2024-04-12T09:50:31Z |
publishDate | 2017-02-01 |
publisher | eLife Sciences Publications Ltd |
record_format | Article |
series | eLife |
spelling | doaj.art-045d17baa315463dbc9a1b7ff08248382022-12-22T03:37:50ZengeLife Sciences Publications LtdeLife2050-084X2017-02-01610.7554/eLife.22352Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglionAdriane G Otopalik0https://orcid.org/0000-0002-3224-6502Marie L Goeritz1Alexander C Sutton2Ted Brookings3Cosmo Guerini4Eve Marder5https://orcid.org/0000-0001-9632-5448Biology Department and Volen Center, Brandeis University, Waltham, United StatesBiology Department and Volen Center, Brandeis University, Waltham, United StatesBiology Department and Volen Center, Brandeis University, Waltham, United StatesBiology Department and Volen Center, Brandeis University, Waltham, United StatesBiology Department and Volen Center, Brandeis University, Waltham, United StatesBiology Department and Volen Center, Brandeis University, Waltham, United StatesNeuronal physiology depends on a neuron’s ion channel composition and unique morphology. Variable ion channel compositions can produce similar neuronal physiologies across animals. Less is known regarding the morphological precision required to produce reliable neuronal physiology. Theoretical studies suggest that moraphology is tightly tuned to minimize wiring and conduction delay of synaptic events. We utilize high-resolution confocal microscopy and custom computational tools to characterize the morphologies of four neuron types in the stomatogastric ganglion (STG) of the crab Cancer borealis. Macroscopic branching patterns and fine cable properties are variable within and across neuron types. We compare these neuronal structures to synthetic minimal spanning neurite trees constrained by a wiring cost equation and find that STG neurons do not adhere to prevailing hypotheses regarding wiring optimization principles. In this highly modulated and oscillating circuit, neuronal structures appear to be governed by a space-filling mechanism that outweighs the cost of inefficient wiring.https://elifesciences.org/articles/22352Cancer borealisneuronal morphologywiring costoptimization principlesdendritic tree |
spellingShingle | Adriane G Otopalik Marie L Goeritz Alexander C Sutton Ted Brookings Cosmo Guerini Eve Marder Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion eLife Cancer borealis neuronal morphology wiring cost optimization principles dendritic tree |
title | Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
title_full | Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
title_fullStr | Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
title_full_unstemmed | Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
title_short | Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
title_sort | sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion |
topic | Cancer borealis neuronal morphology wiring cost optimization principles dendritic tree |
url | https://elifesciences.org/articles/22352 |
work_keys_str_mv | AT adrianegotopalik sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion AT marielgoeritz sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion AT alexandercsutton sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion AT tedbrookings sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion AT cosmoguerini sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion AT evemarder sloppymorphologicaltuninginidentifiedneuronsofthecrustaceanstomatogastricganglion |