Cross-Talk between Wnt Signaling and Src Tyrosine Kinase
Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has been shown to critical for cancer progression for a variety of tissues. Src activity is regulated by a number of post-translational modifications in response to various stimuli. Phosphorylations of Src Tyr419 (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1112 |
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| author | Jung Ki Min Hwee-Seon Park Yoon-Beom Lee Jae-Gyu Kim Jong-Il Kim Jae-Bong Park |
| author_facet | Jung Ki Min Hwee-Seon Park Yoon-Beom Lee Jae-Gyu Kim Jong-Il Kim Jae-Bong Park |
| author_sort | Jung Ki Min |
| collection | DOAJ |
| description | Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has been shown to critical for cancer progression for a variety of tissues. Src activity is regulated by a number of post-translational modifications in response to various stimuli. Phosphorylations of Src Tyr419 (human; 416 in chicken) and Src Tyr530 (human; 527 in chicken) have been known to be critical for activation and inactivation of Src, respectively. Wnt signaling regulates a variety of cellular functions including for development and cell proliferation, and has a role in certain diseases such as cancer. Wnt signaling is carried out through two pathways: β-catenin-dependent canonical and β-catenin-independent non-canonical pathways as Wnt ligands bind to their receptors, Frizzled, LRP5/6, and ROR1/2. In addition, many signaling components including Axin, APC, Damm, Dishevelled, JNK kinase and Rho GTPases contribute to these canonical and non-canonical Wnt pathways. However, the communication between Wnt signaling and Src tyrosine kinase has not been well reviewed as Src regulates Wnt signaling through LRP6 tyrosine phosphorylation. GSK-3β phosphorylated by Wnt also regulates Src activity. As Wnt signaling and Src mutually regulate each other, it is noted that aberrant regulation of these components give rise to various diseases including typically cancer, and as such, merit a closer look. |
| first_indexed | 2024-03-10T03:17:06Z |
| format | Article |
| id | doaj.art-045ed86afbb24d82a2e37b0c54e045c3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:06Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-045ed86afbb24d82a2e37b0c54e045c32023-11-23T10:11:15ZengMDPI AGBiomedicines2227-90592022-05-01105111210.3390/biomedicines10051112Cross-Talk between Wnt Signaling and Src Tyrosine KinaseJung Ki Min0Hwee-Seon Park1Yoon-Beom Lee2Jae-Gyu Kim3Jong-Il Kim4Jae-Bong Park5Department of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, KoreaDepartment of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, KoreaSrc, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has been shown to critical for cancer progression for a variety of tissues. Src activity is regulated by a number of post-translational modifications in response to various stimuli. Phosphorylations of Src Tyr419 (human; 416 in chicken) and Src Tyr530 (human; 527 in chicken) have been known to be critical for activation and inactivation of Src, respectively. Wnt signaling regulates a variety of cellular functions including for development and cell proliferation, and has a role in certain diseases such as cancer. Wnt signaling is carried out through two pathways: β-catenin-dependent canonical and β-catenin-independent non-canonical pathways as Wnt ligands bind to their receptors, Frizzled, LRP5/6, and ROR1/2. In addition, many signaling components including Axin, APC, Damm, Dishevelled, JNK kinase and Rho GTPases contribute to these canonical and non-canonical Wnt pathways. However, the communication between Wnt signaling and Src tyrosine kinase has not been well reviewed as Src regulates Wnt signaling through LRP6 tyrosine phosphorylation. GSK-3β phosphorylated by Wnt also regulates Src activity. As Wnt signaling and Src mutually regulate each other, it is noted that aberrant regulation of these components give rise to various diseases including typically cancer, and as such, merit a closer look.https://www.mdpi.com/2227-9059/10/5/1112WntSrcGSK-3ββ-cateninRho GTPases |
| spellingShingle | Jung Ki Min Hwee-Seon Park Yoon-Beom Lee Jae-Gyu Kim Jong-Il Kim Jae-Bong Park Cross-Talk between Wnt Signaling and Src Tyrosine Kinase Biomedicines Wnt Src GSK-3β β-catenin Rho GTPases |
| title | Cross-Talk between Wnt Signaling and Src Tyrosine Kinase |
| title_full | Cross-Talk between Wnt Signaling and Src Tyrosine Kinase |
| title_fullStr | Cross-Talk between Wnt Signaling and Src Tyrosine Kinase |
| title_full_unstemmed | Cross-Talk between Wnt Signaling and Src Tyrosine Kinase |
| title_short | Cross-Talk between Wnt Signaling and Src Tyrosine Kinase |
| title_sort | cross talk between wnt signaling and src tyrosine kinase |
| topic | Wnt Src GSK-3β β-catenin Rho GTPases |
| url | https://www.mdpi.com/2227-9059/10/5/1112 |
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