Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro
The aim of this study was to compare the protective effects of three dietary flavonoids (apigenin-7-<i>O</i>-glucoside (A7G), isorhamnetin-3-<i>O</i>-rutinoside (I3R), and cyanidin-3-<i>O</i>-glucoside (C3G)) on advanced glycation end products (AGEs)-induced infla...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1026 |
| _version_ | 1797474135703552000 |
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| author | Yishan Fu Yijia Jia Yilin Sun Xiaojing Liu Junjie Yi Shengbao Cai |
| author_facet | Yishan Fu Yijia Jia Yilin Sun Xiaojing Liu Junjie Yi Shengbao Cai |
| author_sort | Yishan Fu |
| collection | DOAJ |
| description | The aim of this study was to compare the protective effects of three dietary flavonoids (apigenin-7-<i>O</i>-glucoside (A7G), isorhamnetin-3-<i>O</i>-rutinoside (I3R), and cyanidin-3-<i>O</i>-glucoside (C3G)) on advanced glycation end products (AGEs)-induced inflammation and vascular endothelial dysfunction. Furthermore, the potential mechanisms of varied effects of those three dietary flavonoids were analyzed by molecular docking analysis. Results showed that C3G (40 μM) achieved the best inhibition on inflammatory cytokines (TNF-α, IL-1β, and IL-6) in AGEs-induced RAW264.7 cells, followed by I3R, and A7G was the weakest. The molecular docking results also showed that C3G exhibited the closest binding with the receptor for AGE. However, I3R (40 μM) demonstrated the best effect in improving endothelial dysfunction in AGEs-induced EA.hy926 cells, followed by C3G, and A7G was the weakest, as evidenced by the molecular docking results of flavonoids with profilin-1. This work may provide knowledge and helpful suggestions regarding the benefits of dietary flavonoids in diabetic vascular complications. |
| first_indexed | 2024-03-09T20:26:48Z |
| format | Article |
| id | doaj.art-04615a7a5b6c4b71ad02f76afaf826c7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:48Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-04615a7a5b6c4b71ad02f76afaf826c72023-11-23T23:33:28ZengMDPI AGNutrients2072-66432022-02-01145102610.3390/nu14051026Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In VitroYishan Fu0Yijia Jia1Yilin Sun2Xiaojing Liu3Junjie Yi4Shengbao Cai5Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaThe aim of this study was to compare the protective effects of three dietary flavonoids (apigenin-7-<i>O</i>-glucoside (A7G), isorhamnetin-3-<i>O</i>-rutinoside (I3R), and cyanidin-3-<i>O</i>-glucoside (C3G)) on advanced glycation end products (AGEs)-induced inflammation and vascular endothelial dysfunction. Furthermore, the potential mechanisms of varied effects of those three dietary flavonoids were analyzed by molecular docking analysis. Results showed that C3G (40 μM) achieved the best inhibition on inflammatory cytokines (TNF-α, IL-1β, and IL-6) in AGEs-induced RAW264.7 cells, followed by I3R, and A7G was the weakest. The molecular docking results also showed that C3G exhibited the closest binding with the receptor for AGE. However, I3R (40 μM) demonstrated the best effect in improving endothelial dysfunction in AGEs-induced EA.hy926 cells, followed by C3G, and A7G was the weakest, as evidenced by the molecular docking results of flavonoids with profilin-1. This work may provide knowledge and helpful suggestions regarding the benefits of dietary flavonoids in diabetic vascular complications.https://www.mdpi.com/2072-6643/14/5/1026advanced glycation end productsdietary flavonoidsendothelial dysfunctioninflammationmolecular docking |
| spellingShingle | Yishan Fu Yijia Jia Yilin Sun Xiaojing Liu Junjie Yi Shengbao Cai Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro Nutrients advanced glycation end products dietary flavonoids endothelial dysfunction inflammation molecular docking |
| title | Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro |
| title_full | Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro |
| title_fullStr | Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro |
| title_full_unstemmed | Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro |
| title_short | Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro |
| title_sort | dietary flavonoids alleviate inflammation and vascular endothelial barrier dysfunction induced by advanced glycation end products in vitro |
| topic | advanced glycation end products dietary flavonoids endothelial dysfunction inflammation molecular docking |
| url | https://www.mdpi.com/2072-6643/14/5/1026 |
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