Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses
Abstract Objective This study aims to describe the behavior of chromosomopathy screenings in euploid fetuses. Methods This is a prospective descriptive study with 566 patients at 11 to 14 weeks of gestation. The associations between ultrasound scans and serological variables were studied. For the...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2022-08-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700646&tlng=en |
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| author | Ximena Carolina Romero Infante Montserrat Uriel Alejandra Gutiérrez María Fernanda Hernández Andres Felipe Hernández Laura Catalina Jiménez Jeadran Nevardo Malagón-Rojas Sara Rincón Franco |
| author_facet | Ximena Carolina Romero Infante Montserrat Uriel Alejandra Gutiérrez María Fernanda Hernández Andres Felipe Hernández Laura Catalina Jiménez Jeadran Nevardo Malagón-Rojas Sara Rincón Franco |
| author_sort | Ximena Carolina Romero Infante |
| collection | DOAJ |
| description | Abstract Objective This study aims to describe the behavior of chromosomopathy screenings in euploid fetuses. Methods This is a prospective descriptive study with 566 patients at 11 to 14 weeks of gestation. The associations between ultrasound scans and serological variables were studied. For the quantitative variables we used the Spearman test; for the qualitative with quantitative variables the of Mann-Whitney U-test; and for qualitative variables, the X2 test was applied. Significance was set at p ≤ 0.05. Results We have found that gestational age has correlation with ductus venosus, nuchal translucency, free fraction of β subunit of human chorionic gonadotropin, pregnancy-associated plasma protein-A and placental growth factor; there is also a correlation between history of miscarriages and nasal bone. Furthermore, we correlated body mass index with nuchal translucency, free fraction of β subunit of human chorionic gonadotropin, and pregnancy-associated plasma protein-A. Maternal age was associated with free fraction of β subunit of human chorionic gonadotropin and pregnancy-associated plasma protein-A. Conclusion Our study demonstrates for the first time the behavior of the biochemical and ultrasonographic markers of chromosomopathy screenings during the first trimester in euploid fetuses in Colombia. Our information is consistent with international reference values. Moreover, we have shown the correlation of different variables with maternal characteristics to determine the variables that could help with development of a screening process during the first trimester with high detection rates. |
| first_indexed | 2024-04-13T02:49:09Z |
| format | Article |
| id | doaj.art-04628555360f4eddb1bd76d6bdc1bd3f |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-04-13T02:49:09Z |
| publishDate | 2022-08-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-04628555360f4eddb1bd76d6bdc1bd3f2022-12-22T03:05:54ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032022-08-0144764665310.1055/s-0042-1744461Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid FetusesXimena Carolina Romero Infantehttps://orcid.org/0000-0002-7040-2705Montserrat Urielhttps://orcid.org/0000-0001-5987-8633Alejandra Gutiérrezhttps://orcid.org/0000-0002-6213-5846María Fernanda Hernándezhttps://orcid.org/0000-0002-5976-8597Andres Felipe Hernándezhttps://orcid.org/0000-0002-3442-8748Laura Catalina Jiménezhttps://orcid.org/0000-0002-9362-5450Jeadran Nevardo Malagón-Rojashttps://orcid.org/0000-0001-5801-936XSara Rincón Francohttps://orcid.org/0000-0002-4594-9151Abstract Objective This study aims to describe the behavior of chromosomopathy screenings in euploid fetuses. Methods This is a prospective descriptive study with 566 patients at 11 to 14 weeks of gestation. The associations between ultrasound scans and serological variables were studied. For the quantitative variables we used the Spearman test; for the qualitative with quantitative variables the of Mann-Whitney U-test; and for qualitative variables, the X2 test was applied. Significance was set at p ≤ 0.05. Results We have found that gestational age has correlation with ductus venosus, nuchal translucency, free fraction of β subunit of human chorionic gonadotropin, pregnancy-associated plasma protein-A and placental growth factor; there is also a correlation between history of miscarriages and nasal bone. Furthermore, we correlated body mass index with nuchal translucency, free fraction of β subunit of human chorionic gonadotropin, and pregnancy-associated plasma protein-A. Maternal age was associated with free fraction of β subunit of human chorionic gonadotropin and pregnancy-associated plasma protein-A. Conclusion Our study demonstrates for the first time the behavior of the biochemical and ultrasonographic markers of chromosomopathy screenings during the first trimester in euploid fetuses in Colombia. Our information is consistent with international reference values. Moreover, we have shown the correlation of different variables with maternal characteristics to determine the variables that could help with development of a screening process during the first trimester with high detection rates.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700646&tlng=engenetic markersscreeningultrasonographychromosomal abnormalitypregnancy |
| spellingShingle | Ximena Carolina Romero Infante Montserrat Uriel Alejandra Gutiérrez María Fernanda Hernández Andres Felipe Hernández Laura Catalina Jiménez Jeadran Nevardo Malagón-Rojas Sara Rincón Franco Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses Revista Brasileira de Ginecologia e Obstetrícia genetic markers screening ultrasonography chromosomal abnormality pregnancy |
| title | Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses |
| title_full | Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses |
| title_fullStr | Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses |
| title_full_unstemmed | Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses |
| title_short | Behavior of the Genetic Markers at Screening during the First Trimester of Pregnancy in Euploid Fetuses |
| title_sort | behavior of the genetic markers at screening during the first trimester of pregnancy in euploid fetuses |
| topic | genetic markers screening ultrasonography chromosomal abnormality pregnancy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700646&tlng=en |
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