Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/22/7031 |
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| author | Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu |
| author_facet | Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu |
| author_sort | Alina Robu |
| collection | DOAJ |
| description | PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection. |
| first_indexed | 2024-03-10T05:18:24Z |
| format | Article |
| id | doaj.art-04636d08937a47a686b98bd69c1e00ba |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T05:18:24Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-04636d08937a47a686b98bd69c1e00ba2023-11-23T00:12:37ZengMDPI AGMaterials1996-19442021-11-011422703110.3390/ma14227031Additives Imparting Antimicrobial Properties to Acrylic Bone CementsAlina Robu0Aurora Antoniac1Elena Grosu2Eugeniu Vasile3Anca Daniela Raiciu4Florin Iordache5Vasile Iulian Antoniac6Julietta V. Rau7Viktoriya G. Yankova8Lia Mara Ditu9Vicentiu Saceleanu10Faculty of Material Science and Engineering, UniversityPolitehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Material Science and Engineering, UniversityPolitehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Material Science and Engineering, UniversityPolitehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Pharmacy, Titu Maiorescu University, 22 Dambovnicului Street, District 4, 040441 Bucharest, RomaniaFaculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine Bucharest, 59 Bulevardul Marasti, 050097 Bucharest, RomaniaFaculty of Material Science and Engineering, UniversityPolitehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, ItalyInstitute of Pharmacy, Department of Analytical, Physical and Colloid Chemistry, I.M. Sechenov First Moscow State Medical University, 8 Trubetskaya Street, Build. 2, 119991 Moscow, RussiaFaculty of Biology, University of Bucharest, Intrarea Portocalelor Street, no. 1-3, 060101 Bucharest, RomaniaFaculty of Medicine, University Lucian Blaga Sibiu, 2A Lucian Blaga Street, 550169 Sibiu, RomaniaPMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection.https://www.mdpi.com/1996-1944/14/22/7031PMMA bone cementspeppermint essential oilsilver nanoparticlesgentamicinantimicrobial properties |
| spellingShingle | Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu Additives Imparting Antimicrobial Properties to Acrylic Bone Cements Materials PMMA bone cements peppermint essential oil silver nanoparticles gentamicin antimicrobial properties |
| title | Additives Imparting Antimicrobial Properties to Acrylic Bone Cements |
| title_full | Additives Imparting Antimicrobial Properties to Acrylic Bone Cements |
| title_fullStr | Additives Imparting Antimicrobial Properties to Acrylic Bone Cements |
| title_full_unstemmed | Additives Imparting Antimicrobial Properties to Acrylic Bone Cements |
| title_short | Additives Imparting Antimicrobial Properties to Acrylic Bone Cements |
| title_sort | additives imparting antimicrobial properties to acrylic bone cements |
| topic | PMMA bone cements peppermint essential oil silver nanoparticles gentamicin antimicrobial properties |
| url | https://www.mdpi.com/1996-1944/14/22/7031 |
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