Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis
The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative st...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-03-01
|
| Series: | Journal of Veterinary and Animal Sciences |
| Subjects: | |
| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_rsdnbh.pdf?t=rsdnbh |
| _version_ | 1797848015049850880 |
|---|---|
| author | M. R. Krishna Nath N. Madhavan Unny Sindhu K. Rajan Usha Narayana Pillai V. Ramnath |
| author_facet | M. R. Krishna Nath N. Madhavan Unny Sindhu K. Rajan Usha Narayana Pillai V. Ramnath |
| author_sort | M. R. Krishna Nath |
| collection | DOAJ |
| description | The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative stress parameters, serummalondialdehyde (MDA) level, total antioxidant status (TAS) and plasma glutathione peroxidase (GSH-Px) activity were studied. The values were compared with the values from six apparently healthy dogs. A significant increase was noticed in the mean values of serum MDA and TAS of diseased animals at the time of presentation when compared to healthy animals whereas the activity of plasma GSH-Px was found to be lower than in healthy dogs. Supplementation with N-acetyl cysteine @ 70 mg/kg or five days was found effective in managing the oxidative injury in the affected animals. |
| first_indexed | 2024-04-09T18:20:35Z |
| format | Article |
| id | doaj.art-0464bde6a9fd4908abcbcba2cbe1d274 |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-04-09T18:20:35Z |
| publishDate | 2023-03-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-0464bde6a9fd4908abcbcba2cbe1d2742023-04-12T06:39:36ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052023-03-01541869010.51966/jvas.2023.54.1.86-90Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritisM. R. Krishna Nath0https://orcid.org/0009-0003-5909-6473N. Madhavan Unny1Sindhu K. Rajan2https://orcid.org/0000-0003-1286-9793Usha Narayana Pillai3https://orcid.org/0000-0003-2925-1471V. Ramnath4https://orcid.org/0000-0003-2215-3502MVSc. scholar, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.Professor and head, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, India.Professor and head, Department of Veterinary Physiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680651, Kerala Veterinary and Animal Sciences University, Pookode, Kerala, India.The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative stress parameters, serummalondialdehyde (MDA) level, total antioxidant status (TAS) and plasma glutathione peroxidase (GSH-Px) activity were studied. The values were compared with the values from six apparently healthy dogs. A significant increase was noticed in the mean values of serum MDA and TAS of diseased animals at the time of presentation when compared to healthy animals whereas the activity of plasma GSH-Px was found to be lower than in healthy dogs. Supplementation with N-acetyl cysteine @ 70 mg/kg or five days was found effective in managing the oxidative injury in the affected animals.https://jvas.in/public_html/upload/article_file/article_file_rsdnbh.pdf?t=rsdnbhhaemorrhagic gastroenteritisoxidative stressn-acetyl cysteine |
| spellingShingle | M. R. Krishna Nath N. Madhavan Unny Sindhu K. Rajan Usha Narayana Pillai V. Ramnath Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis Journal of Veterinary and Animal Sciences haemorrhagic gastroenteritis oxidative stress n-acetyl cysteine |
| title | Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| title_full | Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| title_fullStr | Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| title_full_unstemmed | Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| title_short | Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| title_sort | evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis |
| topic | haemorrhagic gastroenteritis oxidative stress n-acetyl cysteine |
| url | https://jvas.in/public_html/upload/article_file/article_file_rsdnbh.pdf?t=rsdnbh |
| work_keys_str_mv | AT mrkrishnanath evaluationofoxidativestressandefficacyofantioxidanttherapyindogswithhaemorrhagicgastroenteritis AT nmadhavanunny evaluationofoxidativestressandefficacyofantioxidanttherapyindogswithhaemorrhagicgastroenteritis AT sindhukrajan evaluationofoxidativestressandefficacyofantioxidanttherapyindogswithhaemorrhagicgastroenteritis AT ushanarayanapillai evaluationofoxidativestressandefficacyofantioxidanttherapyindogswithhaemorrhagicgastroenteritis AT vramnath evaluationofoxidativestressandefficacyofantioxidanttherapyindogswithhaemorrhagicgastroenteritis |