Autoimmune Hepatitis: A Review with emphasis on its histomorphology
<p><span style="font-family: Calibri;">Autoimmune hepatitis is a chronic inflammatory disorder characterized by periportal inflammation, hypergammaglobulinemia with elevated autoantibodies, and a dramatic response to immunosuppression. Various environmental and genetic influenc...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2012-09-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/6887 |
| Summary: | <p><span style="font-family: Calibri;">Autoimmune hepatitis is a chronic inflammatory disorder characterized by periportal inflammation, hypergammaglobulinemia with elevated autoantibodies, and a dramatic response to immunosuppression. Various environmental and genetic influences can trigger the immune mediated destruction of the liver. A plethora of clinical presentations can be seen ranging from chronic indolent disease to fulminant hepatic failure. Autoimmune hepatitis does not have a pathognomonic feature, and its laboratory, serologic, and histologic manifestations are found in acute and chronic liver disease of diverse causes. Difficulties in distinguishing toxic, drug-related, virus-induced, and autoimmune causes of severe acute liver injury can result in misclassification. Our paper discusses autoimmune hepatitis, giving a detailed overview of its clinical presentation, immunopathogenesis, emphasis on histomorphological changes and the diagnostic criteria.</span></p><p><span style="font-family: Calibri;">Journal of Pathology of Nepal (2012) Vol. 2, 317-323</span></p><p><span style="font-family: Calibri;">DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i4.6887">http://dx.doi.org/10.3126/jpn.v2i4.6887</a></span></p> |
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| ISSN: | 2091-0797 2091-0908 |