Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?
<p>Abstract</p> <p>Background</p> <p>About 20–30% of persons with HIV infection, especially those living in countries with limited resources, experience an immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active form of vit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-04-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/6/1/4 |
| _version_ | 1818118856869150720 |
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| author | Moreno-Reyes Rodrigo Colebunders Robert Mathieu Chantal Conesa-Botella Anali van Etten Evelyne Lynen Lut Kestens Luc |
| author_facet | Moreno-Reyes Rodrigo Colebunders Robert Mathieu Chantal Conesa-Botella Anali van Etten Evelyne Lynen Lut Kestens Luc |
| author_sort | Moreno-Reyes Rodrigo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>About 20–30% of persons with HIV infection, especially those living in countries with limited resources, experience an immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in the clearance of pathogens and influences the level of inflammation and macrophage activation.</p> <p>Presentation of the hypothesis</p> <p>We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to polymorphisms in the vitamin D receptor or in its activating/inactivating enzymes, contributes to the appearance of IRIS. Furthermore, drug interactions with the enzymatic pathways of vitamin D could favour the development of IRIS.</p> <p>Testing the hypothesis</p> <p>Our hypothesis could be explored by a case-control study to assess the prevalence of vitamin D deficiency in HIV-infected patients on antiretroviral treatment who develop and do not develop IRIS.</p> <p>Implications of the hypothesis</p> <p>If the role of vitamin D in IRIS is confirmed, we would be able to screen patients at risk for IRIS by screening for vitamin D deficiency. After confirmation by means of a clinical trial, vitamin D supplementation could be a cheap and safe way to reduce the incidence of IRIS.</p> |
| first_indexed | 2024-12-11T05:00:57Z |
| format | Article |
| id | doaj.art-046718aef7624aab8778777e241d4c05 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-11T05:00:57Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-046718aef7624aab8778777e241d4c052022-12-22T01:20:09ZengBMCAIDS Research and Therapy1742-64052009-04-0161410.1186/1742-6405-6-4Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?Moreno-Reyes RodrigoColebunders RobertMathieu ChantalConesa-Botella Analivan Etten EvelyneLynen LutKestens Luc<p>Abstract</p> <p>Background</p> <p>About 20–30% of persons with HIV infection, especially those living in countries with limited resources, experience an immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in the clearance of pathogens and influences the level of inflammation and macrophage activation.</p> <p>Presentation of the hypothesis</p> <p>We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to polymorphisms in the vitamin D receptor or in its activating/inactivating enzymes, contributes to the appearance of IRIS. Furthermore, drug interactions with the enzymatic pathways of vitamin D could favour the development of IRIS.</p> <p>Testing the hypothesis</p> <p>Our hypothesis could be explored by a case-control study to assess the prevalence of vitamin D deficiency in HIV-infected patients on antiretroviral treatment who develop and do not develop IRIS.</p> <p>Implications of the hypothesis</p> <p>If the role of vitamin D in IRIS is confirmed, we would be able to screen patients at risk for IRIS by screening for vitamin D deficiency. After confirmation by means of a clinical trial, vitamin D supplementation could be a cheap and safe way to reduce the incidence of IRIS.</p>http://www.aidsrestherapy.com/content/6/1/4 |
| spellingShingle | Moreno-Reyes Rodrigo Colebunders Robert Mathieu Chantal Conesa-Botella Anali van Etten Evelyne Lynen Lut Kestens Luc Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? AIDS Research and Therapy |
| title | Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? |
| title_full | Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? |
| title_fullStr | Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? |
| title_full_unstemmed | Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? |
| title_short | Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome? |
| title_sort | is vitamin d deficiency involved in the immune reconstitution inflammatory syndrome |
| url | http://www.aidsrestherapy.com/content/6/1/4 |
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