Antioxidants in Pregnancy: Do We Really Need More Trials?
Human pregnancy can be affected by numerous pathologies, from those which are mild and reversible to others which are life-threatening. Among these, gestational diabetes mellitus and hypertensive disorders of pregnancy with subsequent consequences stand out. Health problems experienced by women duri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/5/812 |
| _version_ | 1797502019130359808 |
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| author | Carolina Di Fabrizio Veronica Giorgione Asma Khalil Colin E. Murdoch |
| author_facet | Carolina Di Fabrizio Veronica Giorgione Asma Khalil Colin E. Murdoch |
| author_sort | Carolina Di Fabrizio |
| collection | DOAJ |
| description | Human pregnancy can be affected by numerous pathologies, from those which are mild and reversible to others which are life-threatening. Among these, gestational diabetes mellitus and hypertensive disorders of pregnancy with subsequent consequences stand out. Health problems experienced by women during pregnancy and postpartum are associated with significant costs to health systems worldwide and contribute largely to maternal mortality and morbidity. Major risk factors for mothers include obesity, advanced maternal age, cardiovascular dysfunction, and endothelial damage; in these scenarios, oxidative stress plays a major role. Markers of oxidative stress can be measured in patients with preeclampsia, foetal growth restriction, and gestational diabetes mellitus, even before their clinical onset. In consequence, antioxidant supplements have been proposed as a possible therapy; however, results derived from large scale randomised clinical trials have been disappointing as no positive effects were demonstrated. This review focuses on the latest evidence on oxidative stress in pregnancy complications, their early diagnosis, and possible therapies to prevent or treat these pathologies. |
| first_indexed | 2024-03-10T03:26:57Z |
| format | Article |
| id | doaj.art-046797be2591488daf40ef88bb29866f |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:26:57Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-046797be2591488daf40ef88bb29866f2023-11-23T09:50:11ZengMDPI AGAntioxidants2076-39212022-04-0111581210.3390/antiox11050812Antioxidants in Pregnancy: Do We Really Need More Trials?Carolina Di Fabrizio0Veronica Giorgione1Asma Khalil2Colin E. Murdoch3Vascular Biology Research Center, Molecular and Clinical Sciences Research Institute, St George’s University of London, London SW17 0QT, UKVascular Biology Research Center, Molecular and Clinical Sciences Research Institute, St George’s University of London, London SW17 0QT, UKVascular Biology Research Center, Molecular and Clinical Sciences Research Institute, St George’s University of London, London SW17 0QT, UKSystems Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UKHuman pregnancy can be affected by numerous pathologies, from those which are mild and reversible to others which are life-threatening. Among these, gestational diabetes mellitus and hypertensive disorders of pregnancy with subsequent consequences stand out. Health problems experienced by women during pregnancy and postpartum are associated with significant costs to health systems worldwide and contribute largely to maternal mortality and morbidity. Major risk factors for mothers include obesity, advanced maternal age, cardiovascular dysfunction, and endothelial damage; in these scenarios, oxidative stress plays a major role. Markers of oxidative stress can be measured in patients with preeclampsia, foetal growth restriction, and gestational diabetes mellitus, even before their clinical onset. In consequence, antioxidant supplements have been proposed as a possible therapy; however, results derived from large scale randomised clinical trials have been disappointing as no positive effects were demonstrated. This review focuses on the latest evidence on oxidative stress in pregnancy complications, their early diagnosis, and possible therapies to prevent or treat these pathologies.https://www.mdpi.com/2076-3921/11/5/812oxidative stresspregnancypreeclampsiaantioxidants |
| spellingShingle | Carolina Di Fabrizio Veronica Giorgione Asma Khalil Colin E. Murdoch Antioxidants in Pregnancy: Do We Really Need More Trials? Antioxidants oxidative stress pregnancy preeclampsia antioxidants |
| title | Antioxidants in Pregnancy: Do We Really Need More Trials? |
| title_full | Antioxidants in Pregnancy: Do We Really Need More Trials? |
| title_fullStr | Antioxidants in Pregnancy: Do We Really Need More Trials? |
| title_full_unstemmed | Antioxidants in Pregnancy: Do We Really Need More Trials? |
| title_short | Antioxidants in Pregnancy: Do We Really Need More Trials? |
| title_sort | antioxidants in pregnancy do we really need more trials |
| topic | oxidative stress pregnancy preeclampsia antioxidants |
| url | https://www.mdpi.com/2076-3921/11/5/812 |
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