Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia
Literatures about case-control study on the association between CYP2D6*10 gene polymorphism and breast cancer were searched from last updated on May, 2014. Odds ratio of CYP2D6*10 gene distributions in breast cancer patients against healthy control were analyzed. STATA 12 software was applied for in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-12-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/20849 |
| _version_ | 1819137368393777152 |
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| author | Zhichen Pu Xiaolong Yuan Xuefeng Zhang Qun Chen Haitang Xie |
| author_facet | Zhichen Pu Xiaolong Yuan Xuefeng Zhang Qun Chen Haitang Xie |
| author_sort | Zhichen Pu |
| collection | DOAJ |
| description | Literatures about case-control study on the association between CYP2D6*10 gene polymorphism and breast cancer were searched from last updated on May, 2014. Odds ratio of CYP2D6*10 gene distributions in breast cancer patients against healthy control were analyzed. STATA 12 software was applied for investigating hereogeneity among individual studies and summarizing effects across studies by proper statistical methods. A total of 812 cases (case group) and 323 cases (control group) were included. Disease free survival of breast cancer patients with CYP2D6*10 wild-type homozygous and heterozygous is higher than that of CYP2D6*10/*10 patients after the tamoxifen treatment, with statistical significance. Disease free survival of breast cancer patients with CYP2D6*10/*10 gene is similar to those with other genotypes after the tamoxifen treatment. This study demonstrated that CYP2D6*10 genotype is unlikely to have any clinical significance for prognosis of breast cancer patients receiving tamoxifen alone. |
| first_indexed | 2024-12-22T10:49:46Z |
| format | Article |
| id | doaj.art-046876a0c1e444b3ba88716785a6d8c1 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-22T10:49:46Z |
| publishDate | 2014-12-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-046876a0c1e444b3ba88716785a6d8c12022-12-21T18:28:49ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882014-12-019410.3329/bjp.v9i4.20849Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in AsiaZhichen Pu0Xiaolong Yuan1Xuefeng Zhang2Qun Chen3Haitang Xie4Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Province Center for Drug Clinical EvaluationDepartment of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Province Center for Drug Clinical EvaluationDepartment of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Province Center for Drug Clinical EvaluationDepartment of Pharmacy, Wuhu Chinese Medicine Hospital, WuhuDepartment of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Province Center for Drug Clinical EvaluationLiteratures about case-control study on the association between CYP2D6*10 gene polymorphism and breast cancer were searched from last updated on May, 2014. Odds ratio of CYP2D6*10 gene distributions in breast cancer patients against healthy control were analyzed. STATA 12 software was applied for investigating hereogeneity among individual studies and summarizing effects across studies by proper statistical methods. A total of 812 cases (case group) and 323 cases (control group) were included. Disease free survival of breast cancer patients with CYP2D6*10 wild-type homozygous and heterozygous is higher than that of CYP2D6*10/*10 patients after the tamoxifen treatment, with statistical significance. Disease free survival of breast cancer patients with CYP2D6*10/*10 gene is similar to those with other genotypes after the tamoxifen treatment. This study demonstrated that CYP2D6*10 genotype is unlikely to have any clinical significance for prognosis of breast cancer patients receiving tamoxifen alone.https://www.banglajol.info/index.php/BJP/article/view/20849Breast cancerTamoxifenCYP2D6*10PolymorphismMeta-analysis |
| spellingShingle | Zhichen Pu Xiaolong Yuan Xuefeng Zhang Qun Chen Haitang Xie Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia Bangladesh Journal of Pharmacology Breast cancer Tamoxifen CYP2D6*10 Polymorphism Meta-analysis |
| title | Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia |
| title_full | Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia |
| title_fullStr | Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia |
| title_full_unstemmed | Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia |
| title_short | Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia |
| title_sort | meta analysis on the association between cyp2d6 10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in asia |
| topic | Breast cancer Tamoxifen CYP2D6*10 Polymorphism Meta-analysis |
| url | https://www.banglajol.info/index.php/BJP/article/view/20849 |
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