The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning
Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interacti...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/5/365 |
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| author | Qian Hui Tan Agimaa Otgonbaatar Prameet Kaur Angelica Faye Ga Nathan P. Harmston Nicholas S. Tolwinski |
| author_facet | Qian Hui Tan Agimaa Otgonbaatar Prameet Kaur Angelica Faye Ga Nathan P. Harmston Nicholas S. Tolwinski |
| author_sort | Qian Hui Tan |
| collection | DOAJ |
| description | Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interactions with different receptors on the cell membrane. PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion. Here, we examine two roles of Otk-1 and Otk-2 in patterning and neurogenesis. We find that Otk-1 is a positive regulator of signaling and Otk-2 functions as its inhibitor. We propose that PTK7/Otk functions in signaling, cell migration, and polarity contributing to the diversity of cellular responses seen in Wnt-mediated processes. |
| first_indexed | 2024-04-25T00:32:53Z |
| format | Article |
| id | doaj.art-0468d6e6377a4462942f40399028c691 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-25T00:32:53Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0468d6e6377a4462942f40399028c6912024-03-12T16:41:27ZengMDPI AGCells2073-44092024-02-0113536510.3390/cells13050365The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and PatterningQian Hui Tan0Agimaa Otgonbaatar1Prameet Kaur2Angelica Faye Ga3Nathan P. Harmston4Nicholas S. Tolwinski5Division of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeWnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interactions with different receptors on the cell membrane. PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion. Here, we examine two roles of Otk-1 and Otk-2 in patterning and neurogenesis. We find that Otk-1 is a positive regulator of signaling and Otk-2 functions as its inhibitor. We propose that PTK7/Otk functions in signaling, cell migration, and polarity contributing to the diversity of cellular responses seen in Wnt-mediated processes.https://www.mdpi.com/2073-4409/13/5/365WntPTK7<i>Drosophila</i> |
| spellingShingle | Qian Hui Tan Agimaa Otgonbaatar Prameet Kaur Angelica Faye Ga Nathan P. Harmston Nicholas S. Tolwinski The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning Cells Wnt PTK7 <i>Drosophila</i> |
| title | The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning |
| title_full | The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning |
| title_fullStr | The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning |
| title_full_unstemmed | The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning |
| title_short | The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning |
| title_sort | wnt co receptor ptk7 otk and its homolog otk 2 in neurogenesis and patterning |
| topic | Wnt PTK7 <i>Drosophila</i> |
| url | https://www.mdpi.com/2073-4409/13/5/365 |
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