Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes

Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes

Purpose: Adefovir is an antiviral drug that exhibits high hydrophilic properties and negligible bioavailability (less than 12%). It is only applied in the form of the ester prodrug adefovir dipivoxil (ADV). The oral bioavailability of ADV is limited (32% to 45%) by its low permeability (Class 3) and...

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Bibliographic Details
Main Authors:	Bahar Darsazan, Alireza Shafaati, Afshin Zarghi, Seyed Alireza Mortazavi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Journal of Pharmacy & Pharmaceutical Sciences
Online Access:	https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/29394

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